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Pharm Final > Anti-histamines Questions > Flashcards

Anti-histamines Questions Flashcards

1
Q

Histamine-1-receptor antagonists

a. Desloratadine has a shorter duration than chlorpheniramine

A

a. False. 3rd gen have the longest duration of action

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2
Q

b. Diphenhydramine increases tremors in patients with Parkinson’s

A

b. False, the antimuscarinic effects of diphenhydramine are used to treat Parkinson’s

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3
Q

c. Diphenhydramine causes constipation as an adverse effect

A

c. True, antimuscarinic effects cause constipation

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4
Q

d. Chlorpheniramine is used to treat rhinitis caused by rhinovirus

A

d. True, antimuscarinic effects dry up nasal secretions

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5
Q

e. Promethazine causes drowsiness as an adverse effect

A

e. True

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6
Q

Antihistamines: therapeutic indications:

a. Desloratadine: allergic rhinitis

A

a. True.

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7
Q

Antihistamines: therapeutic indications:

b. Diphenhydramine: insomnia

A

b. True

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8
Q

Antihistamines: therapeutic indications:

c. Doxylamine: dry cough

A

c. True. Antimuscarinic effects

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9
Q

Antihistamines: therapeutic indications:

d. Cyclizine: nausea and vomiting

A

d. True. Cyclcizine is indicated for labyrinthe disorders, as an anti-emetic and for motion sickness

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10
Q

Antihistamines: therapeutic indications:

e. Loratadine: motion sickness

A

e. False.

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11
Q

The following histamine-1-receptor antagonists are correctly matched with their clinical use:
a. Cyclizine: nausea and vomiting

A

a. True

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12
Q

The following histamine-1-receptor antagonists are correctly matched with their clinical use:
b. Promethazine: treatment of pruritis

A

b. True (think of anaesthetics)

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13
Q

The following histamine-1-receptor antagonists are correctly matched with their clinical use:
c. Diphenhydramine: treatment of insomnia

A

c. True

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14
Q

The following histamine-1-receptor antagonists are correctly matched with their clinical use:
d. Loratadine: vertigo

A

d. False

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15
Q

The following histamine-1-receptor antagonists are correctly matched with their clinical use:
e. Desloratadine: cough suppressant

A

e. False. Need antimuscarinic properties

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16
Q

Antihistamines:

a. Desloratadine causes more sedation than doxylamine

A

a. False. Gen 3 vs 1

17
Q

b. Cyclizine has a longer duration of action than loratadine

A

b. False: Gen 1 vs 2

18
Q

c. Desloratadine is used to treat chronic urticaria

A

c. True. 2nd or 3rd gen antihistamine

19
Q

d. Loratadine is used to treat allergic rhinitis

A

d. True

20
Q

e. Diphenhydramine decreases tremor in patients with Parkinsonism

A

e. True. Antimuscarinic effects

21
Q

The following antihistamines cause sedation

a. diphenhydramine

A

a. True

22
Q

The following antihistamines cause sedation

b. promethazine

A

b. True

23
Q

The following antihistamines cause sedation

c. cyclizine

A

c. True

24
Q

The following antihistamines cause sedation

d. loratadine

A

d. False

25
Q

The following antihistamines cause sedation

e. chlorpheniramine

A

e. True

26
Q

A 56-year old truck driver with a history of allergic rhinitis, treated with promethazine, presents to you at the pharmacy. He is looking for an oral antihistamine (as he does not like nasal sprays) which he can use that will
not cause as much daytime sedation as his current medicine. What is the drug of choice in this patient?

A

Loratadine

27
Q

Antihistamines

a. diphenhydramine is indicated in atopic dermatitis

A

a. True, want a 1st gen antihistamine with anti-pruritic and sedative effects

28
Q

Antihistamines

b. loratadine is indicated in the management of rhinorrhoea due to the common cold

A

b. False, want a 1st gen antihistamine with anti-muscarinic effects to dry up secretions

29
Q

Antihistamines

c. diphenhydramine is an antitussive

A

c. False, 1st gen antihistamine

30
Q

Antihistamines

d. desloratadine has a shorter duration of action than diphenhydramine

A

d. False, new agents of a longer DOA

31
Q

Antihistamines

e. doxylamine is safe to use in pregnancy

A

e. True, safe in pregnancy

Pharm Final (25 decks)

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