psilocybin Flashcards
street name
mushrooms or “shrooms”
what is the active ingredient in psilocybin
psilocin - lipid soluble indole
similar to LSD
how is psilocybin taken
ingestion
metabolites are the effective and require to be metabolized
set and setting
tone of trip related to and based on the pleasantness or aversiveness of your environment
your atmosphere around you will affect your type of high
how does psilocybin effect
partial agonist (less intense from LSD)
affects serotonin 5HT-2A receptor (not 1A tho)
prefrontal cortex
potentially insula
dopamine role in psilocybin
unsure
basal ganglia - but no affinity for D2 receptor
psilocybin tolerance and dependance
acute tolerance, wait a week to dissipate
no dependance
cross tolerance psilocybin
LSD and phenethylamines
potentiation os psilocybin
MAO inhibitors prolong high
complication with MDD because antidepressants
psilocybin therapeutic uses
reduction of 5-HT-2A receptors alleviates OCD symptoms
biochemical effect- not just emotional
good Friday experiment
priest takes shrooms to increase mystical meaning and have positive changes in behaviour
effects seen weeks/months after treatment
ibotenic acid
structurally similar to glutamate- receptor agonist
functionally similar to acetylcholine
metabolite and drug is effective therefor more potent
takes an hour to kick in
euphoria, vivid coloured hallucinogenic, sedated dissociated
can lead to brain damage - excitotoxicity
dextromethorphan protects against
