cocaine

Question 1

benzoylmethylcegonine

Answer 1

originated from the coca plant

related to serotonin norepinephrine and dopamine but not structurally

Question 2

coca-cola

Answer 2

cocoa leaf (coca) kola nut (caffeine)
removed coca from leaf
pepsi is decocainized flavour essence

Question 3

benzyoylmethylecgonine adnimistration

coca leaf

Answer 3

chewed or tea

alleviates pain and suppresses appetite

Question 4

benzyoylmethylecgonine adnimistration

cocaine

Answer 4

inhaled:
- paste
- freebase
- crack
insufflated/injected:
- hydrochloride (salt form)

Question 5

cocaine as a reuptake inhibitor

Answer 5

blocks dopamine transport protein leaving more in the synapse- post synaptic reactivation
brings feelings of pleasure
in high doses can show symptoms of Schizophrenia

Question 6

problem with cocaine as an inhibitor

Answer 6

• euphoria is induced by acute doses implying serotonin

- dopamine transporter antagonists don’t induce same effects

Question 7

cocaine and amphetamine regulated transcript

Answer 7

CART
- neuromodulator endogenous to the body 
- stored with dopamine in vesicles 
activated in starvation 
Antagonize sodium channels produce anesthesia

Question 8

short term effects of cocaine

Answer 8

enhance self esteem
giddiness
increase talkativeness

Question 9

long term cocaine effects

Answer 9

anxiety/depression - down regulation in limbic
motor problems- down reg in mid brain
death
delay discounting: different evaluation of outcomes because of time delay

Question 10

cocaine tolerance

Answer 10

acute- imply serotonin
coke out: dip at the end of high (10-12 hours)
freeze: psychic numbing
let down depression: after first dose from coke out

Question 11

cocaine physiological effects

Answer 11

slow tolerance

heart rate and blood pressure