DMT Flashcards
dimethyltryptamine
DMT- “businessmans LSD”
where is DMT found
tree bark- mimosa hostilis
what molecule is DMT similar to
tryptamine family-
structurally similar to serotonin
what is DMT functionally similar to
psilocybin
similar mechanism of action
structure-activity relationship
relationship between a chemicals structure and biological activity
what is DMT in other where is the enzyme responsible for DMT synthesis found
in the body (not brain)
tryptamine are naturally synthesized into serotonin
DMT in cancerous human cells
cancerous cells produce DMT like substance
can be signalling - unsure
DMT debate
if it is naturally found in the body or not
DMT as an agonist
agonizes dopamine and serotonin
agonises o1, 5HT-2A and 5HT-2C
3 stages of DMT
1- insula: auditory hallucinations
2- amygdala: waiting room- fear and suspension
3- prefrontal cortex: machine elves, other side, hyperspace
machine elves
prescience of humanoid-like half technological half organic beings
might speak different languages but understandable
SNDRA
serotonin norepinephrine dopamine releasing agent
how is DMT intaken
inhalation or injection
“snuff”
what is the problem with ingestion
MAO enzyme deactivates DMT molecule
solution: if you provide MAO inhibitor
ayahuasca
brew which includes plant derived DMT and harmine - MAO-I
longer high
similar experience to psilocybin but more intense
la purga- intense vomiting/diarrhea
DMT cross tolerance
no cross tolerance to LSD- occupies receptor and comes off
LSD has cross tolerance to DMT- LSD occupies receptor and doesn’t come off
DMT dependance
no physical but possible psychological
ayahuasca: no addiction potential
what is the Hoasca project
found that ayahuasca sect adolescents had 7x lower anxiety, body dysmorphism, and attention problems
possible interference of other variables
insight oriented psychotherapy
behavioural reconstructing individuals who have PTSD or anxiety that involves rationalization
individuals who have depression/addiction provides therapeutic insight (fears/desires)
DMT therapeutic use
elicits/brings forth traumatic experience
multiplicity of perspectives
allows hebbian synapse to form - frontal lobe, insula and amygdala involved
