DMT Flashcards

1
Q

dimethyltryptamine

A

DMT- “businessmans LSD”

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2
Q

where is DMT found

A

tree bark- mimosa hostilis

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3
Q

what molecule is DMT similar to

A

tryptamine family-

structurally similar to serotonin

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4
Q

what is DMT functionally similar to

A

psilocybin

similar mechanism of action

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5
Q

structure-activity relationship

A

relationship between a chemicals structure and biological activity

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6
Q

what is DMT in other where is the enzyme responsible for DMT synthesis found

A

in the body (not brain)

tryptamine are naturally synthesized into serotonin

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7
Q

DMT in cancerous human cells

A

cancerous cells produce DMT like substance

can be signalling - unsure

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8
Q

DMT debate

A

if it is naturally found in the body or not

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9
Q

DMT as an agonist

A

agonizes dopamine and serotonin

agonises o1, 5HT-2A and 5HT-2C

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10
Q

3 stages of DMT

A

1- insula: auditory hallucinations
2- amygdala: waiting room- fear and suspension
3- prefrontal cortex: machine elves, other side, hyperspace

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11
Q

machine elves

A

prescience of humanoid-like half technological half organic beings
might speak different languages but understandable

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12
Q

SNDRA

A

serotonin norepinephrine dopamine releasing agent

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13
Q

how is DMT intaken

A

inhalation or injection

“snuff”

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14
Q

what is the problem with ingestion

A

MAO enzyme deactivates DMT molecule

solution: if you provide MAO inhibitor

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15
Q

ayahuasca

A

brew which includes plant derived DMT and harmine - MAO-I
longer high
similar experience to psilocybin but more intense
la purga- intense vomiting/diarrhea

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16
Q

DMT cross tolerance

A

no cross tolerance to LSD- occupies receptor and comes off

LSD has cross tolerance to DMT- LSD occupies receptor and doesn’t come off

17
Q

DMT dependance

A

no physical but possible psychological

ayahuasca: no addiction potential

18
Q

what is the Hoasca project

A

found that ayahuasca sect adolescents had 7x lower anxiety, body dysmorphism, and attention problems
possible interference of other variables

19
Q

insight oriented psychotherapy

A

behavioural reconstructing individuals who have PTSD or anxiety that involves rationalization
individuals who have depression/addiction provides therapeutic insight (fears/desires)

20
Q

DMT therapeutic use

A

elicits/brings forth traumatic experience
multiplicity of perspectives
allows hebbian synapse to form - frontal lobe, insula and amygdala involved