mescaline

Question 1

trimethoxyphenthylamine

Answer 1

mescaline- found in peyote

stress response in plants

Question 2

mescaline structural similarity

Answer 2

catecholamines

- behavioural reward and or learning

Question 3

mescaline functional similarity

Answer 3

LSD and psilocybin

- psychological effects similar to hallucinations

Question 4

how was mescaline used

Answer 4

as a potency measure - other things were compared

Question 5

mescaline agonist

Answer 5

1. serotonin- 5HT-2A
   hallucinations: visual (kaleidoscope and cubism) and auditory
2. norepinephrine- in locus coeruleus
   leads to glutamate release in cerebral cortex

Question 6

mescaline intake

Answer 6

ingested as peyote buttons or mescaline pills (hard to cross BBB but buttons have other chemicals to help)

Question 7

states of mescaline

Answer 7

1. physiological: sympathetic system (30-1hr)
norepinepherine 
2. psychological effects (1-2 hr)
visual, auditory hallucinations
serotonin (?)
3. entheogenic effects- (2hr+)
inner peace, tranquility, euphoria 
dopamine

Question 8

mescaline tolerance

Answer 8

acute with repeated use
- to hallucinogenic properties not attentional
cross tolerance with LSD and psilocybin (2A receptor)

Question 9

mescaline tolerance

Answer 9

no physical - even tho targets dopaminergic

psychological tolerance is uncommon

Question 10

diathesis stress model

Answer 10

individuals who have capacity for mental disorders gravitate towards substances and trigger system that is already existent

Question 11

therapeutic uses

Answer 11

ability to focus attention and move attention around (norepinephrine)
dopamine might be synthesized from norepinephrine later and doesn’t manifest reward characteristics - no addiction
could be possibly used in ADHD