LSD Flashcards
LSD
lysergic acid diethylamide
LSD fungus
ergoline fungus
caused Salem witch hunts
toxic
when was LSD synthesized and how
1943- scientist accidentally ingested and discovered properties
LSD chemical properties
indole nucleus - serotonin
volatile, water soluble, oxidize, photo sensitive
potency of LSD
highly potent -
1 dose = 50-150ug
sympathomimetic
mimics the activity of the sympathetic nervous system
- physiological arousal of fight/flight
- parasympathetic suppression
anorectic effects (appetite suppressant)
process of LSD high
onset- no effects but relaxation (0-30 min)
plateau - images with eyes closed, multilevel reality, distorted visual input - visual cortex/locus coeruleus (30 min- 2 hrs)
peak- emotion/panic, timelessness, disembodiment - prefrontal cortex ( 3-5hrs)
what receptors does LSD effect
visual cortex receptors 5HT-1A and 5HT-2A
what is model object competition
ability to classify and complete objects
decreased activity in occipital lobe
LSDs effects on the 5-HT2A receptor
metabotropic receptor in the locus coeruleus
excites this receptor on glutamate and GABA
inhibits the other serotonin receptors
refinement and salience of signals
- increase sensory signals (threshold)
2. decrease spontaneous signals (noise)
why is perception altered in LSD
because glutamate is released in the cerebral cortex
why are psychotic actions seen in LSD
because dopamine and serotonin interact
JAMES LANGE THEORY
tolerance and dependance in LSD
tachyphylaxis (acute) - you have to wait a few days before doing again because little to nothing happens
no physical dependance or withdrawl
cross tolerance in LSD
tryptamine family - shrooms, DMT
