marijuana

Question 1

phytocannabinoids

Answer 1

delta 9 tetryhydrocannabinoid - dronabinol
- active metabolites: cannabinol
- analogues exert unique effects 
- metabolites exert unique effects 
lipid soluble

Question 2

synthetic alternatives

Answer 2

name: K2 or spice
- affect same receptor we know marijuna does but could be different structure
stimulant and hallucinogenic properties

Question 3

aminoalkylindoles

Answer 3

anti-inflammatory, anti-hyperalgesia

Question 4

potency

Answer 4

hashish is more potent
more THC in hashish than marijuana
modern strains have different concentrations

Question 5

dose dependant effects

Answer 5

light headed (buzz) - euphoric (high)- calm (stoned)

Question 6

intake

Answer 6

inhalation- lose some THC to smoke and absorption in lungs

ingestion- lose some THC to metabolism deactivating

Question 7

contact high

Answer 7

second hand inhalation resulting in psychoactive levels

Question 8

cannabinoid as an agonist

Answer 8

partial agonist- endocannabinoid system

stimulating effect: motor inhibition, mood elevation, cognition, pain relief, appetite

Question 9

NT in endocannabinoid

Answer 9

anadamide, 2-AG

Question 10

behavioural effects of THC

Answer 10

low dose: increase motor activity decrease coordination

high dose: decrease motor activity increase reaction time

Question 11

driving simulation

Answer 11

problem: generalizability and compensatory reactions

Question 12

amotivational syndrome

Answer 12

lack of motivation to engage in productive activities
- no evidence for reward based strategies: opposite found
may be if self motivated or non-reward tasks

Question 13

cognitive effects of THC

Answer 13

low dose: memory deficits with no attention impair
high dose: memory, reasoning and attention impair
diminished LTP in hippocampus

Question 14

decelerated time

Answer 14

perception of time being slowed down

associated with stoned face- reduce blood flow to cerebellum

Question 15

temporal disintegration

Answer 15

alteration in perceptions associated with time

Question 16

flight of ideas

Answer 16

spontaneous seemingly random thoughts

subjectively reported as racing thoughts

Question 17

executive function impairment

Answer 17

shown in abstinent chronic users

disorganized UWM/shift

Question 18

long term effects

Answer 18

gateway: support for process but not likelihood of outcome, used as scare tactic
- no difference in verbal fluency and divided attention

Question 19

correlated vulnerabilities

Answer 19

drug use accounted for by users reason for taking the drug

Question 20

resident study

Answer 20

participants became suspicious, paranoid, agitated
- down reg of receptors
irritable when no access - appetite suppression and insomnia
cannabis dependance- substance
cannabis withdrawal syndrome- irritable/activity/anxiety

Question 21

cannabinoid hyperemesis syndrome

Answer 21

nausea vomiting and colicky abdominal pain as a result of weekly cannabis use for years
relief: hot baths

Question 22

drug discriminability

Answer 22

high drug discriminability

0 confound with opioids but not stimulants