Potnatal Development Flashcards
__________ only stimulate the growth of neurons; they do not influence their wiring scheme.
Neurotrophins
Why does botox poisoning last for such a long time?
Because the poisoned axons die off – importantly, it is not because “the toxin is still around”
_____________ in a neuron is predictive of its death.
Inactivity
What lab method is principally used to study neurogenesis?
Radiolabelled nucleotide precursors
Give an example of apoptosis in neurogenic development.
Muscle fibers often start out innervated by multiple neurons; as time passes, however, motor neurons die off. Ultimately, each motor unit is innervated by only one motor neuron.
Define active zone.
The area of the presynaptic neuron in which vesicles and calcium channels are concentrated
What proteins are involved in the alignment of pre- and postsynaptic neurons?
1) cadherins and protocadherins
2) contactins, contactin associated-proteins
3) pre: neurexins and calcium channels
post: neurogligia and PSD95
Give an example of selective synapse elimination in neurogenesis.
Motor neurons start out innervating multiple muscle fibers; as time passes, the weaker connections die. The strongest neuromuscular junction remains, leaving a one-to-one ratio of motor neurons to muscle fibers.
Another flashcard mentioned that selective synapse elimination occurs at the neuromuscular junction. Where are other locations in which this occurs?
The cerebellum and the visual and auditory cortices
Plasticity can lead to structural changes in _________ terminals.
both the pre- and postsynaptic
Myelination predominantly takes place _____________ (time period).
postnatally
What is the most prominent feature of postnatal neurogenic development?
Increase in synapse density
Most forms of autism spectrum disorder are ______-genic.
poly
Rett syndrome occurs due to defects in ____________.
MECP2 (a protein involved in synapse maturation)
On what chromosome do Prader-Willi and Angelman occur?
15
