Pharmacologic Treatment of Headaches Flashcards

1
Q

Which abortive treatments for migraine should be avoided in someone with ischemic vascular disease?

A

Triptans

Ergots

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2
Q

NSAIDs are avoided in those with _________. Why?

A

acute gastritis; NSAIDs (most) inhibit COX-1, which secretes protective mucus in the stomach

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3
Q

Ergots are ____________ treatments.

A

abortive

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4
Q

The vascular events in migraines appear to have two phases: ________________.

A

first vasoconstriction then vasodilation

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5
Q

Drug delivery can be impacted by the tendency to have _____________ with migraines.

A

nausea, vomiting, or GI dysmotility

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6
Q

Do not concurrently use ergots and triptans. Why?

A

Because their vasoconstrictive effects can be additive

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7
Q

What is the mechanism of ergots?

A

5HT-1b/1d agonist

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8
Q

When should you initiate prophylactic treatment for migraines?

A

When the migraines are frequent (more than four per month), disabling, or long-lasting

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9
Q

Which should you use first, triptans or ergots?

A

Triptans. Ergots have greater toxicity.

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10
Q

How long do prophylactic treatments take to become effective?

A

4-6 weeks

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