CNS Neuropathology Flashcards
The _____________ often gets “chewed up” in MS.
corpus callosum
It is possible to have enlarged ventricles without needing a shunt. Explain.
People can have enlarged ventricles due to loss of periventricular tissue, called hydrocephalus ex vacuo.
MS lesions in the brain often appear at the _______________.
gray-white junction (specifically veins)
MS is more common in _____________ but worse in _____________.
women; men
Immunohistochemical staining of ____________ allows for better identification of MS plaques.
myelin basic protein
Looking at a gross brain specimen, how can you tell communicating hydrocephalus?
The outer edges of the brain (near the meninges) will be scarred –preventing the CSF from getting into the sinuses.
Enhancing rings are ___________.
abscesses
Emboli usually appear at the _________________.
gray-white junction
Lewy body dementia spreads from _______________.
the substantia nigra to the limbic system to the cortex
The earliest effects of alcohol seem to be on _____________.
white matter
Chronic alcohol abuse leads to ________________.
cortical atrophy and meningeal fibrosis
What part of the cerebellum most often gets damaged in chronic alcohol abuse?
The superior/rostral cerebellar vermis
While MS mostly affects _________ matter, __________ matter is also affected.
white; gray
Neurocysticercosis might result from eating what?
Tapeworm-infested pork
Toxoplasmosis of the brain is often seen in _____________ patients and presents with _________________.
AIDS or otherwise immunocompromised; mononucleosis-like illness and maculopapular rash
