Physiology in Pregnancy Flashcards

1
Q

describe the breast changes in pregnancy

A

The breasts increase in size and vascularity resulting in them becoming warm, tense and tender.
There is increased pigmentation of the areola and nipple.
A secondary areola appears.
Montgomery tubercles appear on the areola.
Colostrum like fluid can be expressed from the end of the 3rd month.

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2
Q

why does systemic vascular resistance fall during pregnancy?

A

decreased afterload

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3
Q

what is the main indirect cause of maternal death?

A

CV disease

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4
Q

how much does blood volume increase during pregnancy

A

50-70%

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5
Q

what is increased in CV in pregnancy

A
blood flow
HR
CO
SV
O2 consumption
red cell mass
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6
Q

in the supine position there is a reduction in CO of a pregnant women, how much and why?

A

25%

decreased venous return

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7
Q

by how much does red cell mass increase in pregnancy?

A

40%

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8
Q

what causes the physiological anaemia in pregnacny?

A

dilution

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9
Q

what doe the changes during pregnancy in the CVS result in?

A

warm hands and feet

pregnancy glow

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10
Q

why are pregnant women more prone to nose bleeds?

A

nasal mucosa has increase blood flow

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11
Q

how much blood does each contraction use?

A

500ml

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12
Q

what does pain during labour cause? in regards to the CVS

A

increased catecholamine release which increases BP and heart strain

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13
Q

how does CO change during labour?

A

increased bt 10%

80% in 1st hr post delivery

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14
Q

why do you give epidurals to women with cardiac issues?

A

takes away pain

therefore decreases strain on heart and BP

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15
Q

describe the post partum CV changes

A

By 3 months most of the changes have returned to normal. Blood volume decreases by 10% in the first 3 days post-delivery. BP initially falls then increases again days 3-7, pre-pregnant levels by 6 weeks. SVR increases over the first 2 weeks to 30% above delivery levels. HR returns to pre-pregnant state over 2 weeks. CO increases by up to 80% in the 1st hour post-delivery then continues to fall over the next 24 weeks.

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16
Q

describe the respiratory changes in pregnancy

A

There a significant (20%) increase in oxygen demand. 40-50% increase in minute ventilation. Respiratory rate and tidal volume increases whilst there is decreased functional residual capacity. PERF and FEV1 are unchanged. PCO2 is decreased. Pregnancy is essentially a state of compensated respiratory alkalosis. Asthma doesn’t really change during pregnancy because progesterone causes bronchodilatation. Most women get psychological SOB that gets better by moving around.

17
Q

describe the renal changes in pregnancy

A

Dramatic dilatation of the urinary collecting system which is more pronounced on the right. Increased renal plasma flow by 60-80% at end of second trimester. GFR increases and creatinine clearance increases by up to 50%. Protein excretion is increased. Microscopic haematuria may be present. 80% of women develop oedema. Glycosuria is common. Urate increases with gestation. Urea is decreased, creatinine decreased.

18
Q

describe the haematological changes in pregnancy

A

Plasma volume increases cf birthweight. Decreased haemoglobin, haematocrit, rcc. No change in MCV and MCHC. Decreased platelet count as a dilutional factor – gestational thrombocytopenia. 2-3-fold increase in requirement for iron. 10-20-fold increase in folate requirements. WCC increases. Hypercoagulable state.

19
Q

lab values in pregnancy: Hb

A

decreased

20
Q

lab values in pregnancy: WCC

A

increased

21
Q

lab values in pregnancy: platelets

A

decreased/no change

22
Q

lab values in pregnancy: CRP

A

no change

23
Q

lab values in pregnancy: ESR

A

increased - not done in pregnancy

24
Q

lab values in pregnancy: Urea

A

decreaased

25
Q

lab values in pregnancy: creatinin

A

decreased

26
Q

lab values in pregnancy: urate

A

decreased but increases with gestation

27
Q

lab values in pregnancy: 24hr protein

A

increased

28
Q

lab values in pregnancy: total protein

A

decreased

29
Q

lab values in pregnancy: albumin

A

decreased

30
Q

lab values in pregnancy: AST/ALT/GGT

A

decrease/no change

31
Q

lab values in pregnancy: alk phos

A

ver increased as placenta can produce

32
Q

lab values in pregnancy: bile acids

A

no changw

33
Q

lab values in pregnancy: D-dimer

A

increased - not used in pregnancy so don’t know what upper limiti is