Anaesthetics Pain Flashcards
what are the patient benefits for treating pain?
physical - better sleep and appetite
fewer medical complications
psychological - reduced suffering, less depression and anxiety
what are the family benefits for treating pain?
improved functioning as a family member
able to keep working
what are the societal benefits for treating pain?
lower health costs
able to contribute to community
how can you classify pain?
duration - acute/chronic/acute on chronic
cause - cancer/non-cancer
mechanism - nociceptive/neuropathic
compare acute and chronic pain
Acute - recent onsent, probably limited duration
Chronic - lasts > 3 months, beyond normal healing, no identifiable cause
compare nociceptive and neuropathic pain
In nociceptive pain there is obvious tissue injury or illness. It is also called physiological or inflammatory pain. Nociceptive pain serves a protective function. This type of pain is sharp or dull and well localised.
Neuropathic pain results from nervous system damage or abnormality. Tissue injury may not be obvious. Neuropathic pain does not serve a protective function. This type of pain may be described as: burning, shooting ± numbness, pins and needles. It is not well localised.
what are the 4 steps of pain physiology?
periphery
spinal cord
brain
modulation
describe the periphery part of pain physiology
- Tissue injury
- Release of chemicals e.g. PGs, substance P
- Stimulation of nociceptors
- Signal travels in A𝛿 or C nerve to spinal cord•
describe the spinal cord part of pain physiology
- Dorsal horn is the first relay station
- A𝛿 or C nerve synapses with second nerve
- Second nerve travels up on contralateral side of spinal cord
describe the brain part of pain physiology
• Thalamus is the second relay station • Connections to many parts of the brain o Cortex – expecting it to hurt o Limbic system o Brainstem – pain response • Pain perception occurs in the cortex
describe the modulation part of pain physiology
- Descending pathway from brain to dorsal horn
- Usually decreases pain signal
- People who do this more effectively experience less pain
- Serotonin and dopamine reuptake
how does neuropathic pain come about. give examples of it
• Abnormal processing of pain signal • Nervous system damage or dysfunction • Needs to be treated differently • Examples o Nerve trauma, diabetic pain (damage) o Fibromyalgia, chronic tension headache (dysfunction) • Common after thoracic surgery o Intercostal nerves pulling and retraction • Breast surgery
examples of simple analgesics
paracetamol
NSAIDs
examples of mild opioids
codeine, dihydrocodeine
examples of strong opioids
morphine, oxycodone, fentanyl
what other drugs (classes) can be used to treat pain?
tramadol antidepressants - amitriptyline, duloxetine anticonvulsants - gabapentin ketamine local anaesthetics topical agents - capsaicin
what class of drug is tramadol?
mixed opiate and 5HT/NA reuptake inhibitor