PharmacoDYNAMICS

Question 1

2 core aspects of PHARMACODYNAMICS:

Answer 1

• Mechanism of Drug Action (MOA)
• Pharmacologic effects – desired effects

Question 2

– specific biochemical interaction through which a drug substance produces its pharmacological effect

Answer 2

Mechanism of Drug Action (MOA)

Question 3

• includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor.

Answer 3

Mechanism of Drug Action (MOA)

Question 4

when 2.5% Phenylephrine interacts with alpha1 receptors at dilator pupillae

is an example of:

Answer 4

Mechanism of Drug Action (MOA)

Question 5

specific molecular protein or macromolecule (DNA) which is a component of cells, biologic system, microorganisms, other foreign bodies/cancer cells, into which the drug interacts to initiate chain of biochemical events leading to the drug’s desired effect

Answer 5

Receptor

Question 6

Receptors follows the “_____” principles of drug interactions

Answer 6

Lock & Key

Question 7

Receptors- should be________ to bring about the effect

Answer 7

selective & modifiable

Question 8

Classifications of receptors:

Answer 8

• Kinase receptors
• Ion channels
• G protein-coupled receptors
• Intracellular receptors

Question 9

Receptor sites/types:

Answer 9

Type 1

Type 2

Type 3

Question 10

receptor– at cell membrane (most common)

Answer 10

Type 1 receptor

Question 11

receptor at cytoplasm

Answer 11

Type 2 receptor

Question 12

receptor at nucleus

Answer 12

Type 3 receptor

Question 13

– amount of attraction between drug and receptor

Answer 13

Affinity

Question 14

Drugs with _____ binds to receptor even at low conc. (more potent)

Answer 14

High Affinity

Question 15

moderate-low affinity requires _______ drug concentration.

Answer 15

Higher

Question 16

kinds of Binding force (Bond) between drug and receptor:

Answer 16

1. Covalent Bond
2. Van der Waals bond
3. hydrogen bond
4. Ionic Bond
5. Hydrophobic Bond

Question 17

– strongest bond and produced irreversible effect

Answer 17

Covalent Bond

Question 18

weakest bond

most important

because most of drugs contain cationic and anionic groups, reversible

Answer 18

Van der Waals Bond

Question 19

– affect only one type of receptor and produces a specific response

Answer 19

Drug Selectivity

Question 20

drug will interacts to different receptor site

Answer 20

Drug Non-selective

Question 21

when 2.5%Phenylephrine → acts only on alpha1 receptor

is an example of?

Answer 21

Drug Selectivity

Question 22

when 5% Epinephrine → can interacts with all subtypes of alpha and subtype of B-receptors (A1,A2) (B1, B2, B3)

is an example of?

Answer 22

Non-selective Drug