Fundamentals of Pharmacology Flashcards
science which deals with all knowledge about drugs
Pharmacology
– action of the body in the drugs once it is introduced into the BODY
Pharmacokinetics
how the body handle the drugs
Pharmacokinetics
- “what the body does to the drugs”
Pharmacokinetics
movement of drug molecules from the site of administration (routes) to the systemic blood circulation
Absorption / Bioavailability
movement of drug molecules to the different parts of the body until some of the drugs reach the site of action
Distribution
– transformation/change of drug molecules from bound form (inactive) to free/unbound form active or reverse or leads to formation other forms of drug, active or inactive, called inactive metabolites (usually inactive → no effect)
Metabolism / Biotransformation
Organs involved in Drug metabolism
- Liver
- Kidneys
- Lungs
- Adrenal or Suprarenal glands
movement of drug molecules out of the body → termination of drug effect (E)
Elimination / Excretion
- disappearance of drug molecules from the blood/body → termination of drug effect (E)
Excretion/Elimination
Organs involved for drug excretion:
- Kidneys
- Liver
- Glands
- Lungs
- Git
side effects of Tetracycline:
Yellow discoloration of Body secretions
action of drugs in the body
Pharmacodynamics
- “what the drug does to the body
Pharmacodynamics
study of biochemical and physiological effects of drugs in the body or microorganisms and mechanism of drug action and the relationship between drug concentration and effects
Pharmacodynamics