Drug Inter-actions (Agonist / Antagonist )

Question 1

Types of Drug-Drug Interactions:

Answer 1

1. Receptor–Drug interactions
2. Non-receptor–Drug interactions

Question 2

kinds Non-receptor–Drug interactions:

Answer 2

a. Antidote for poisons
b. Chelating agents
c. antagonist/inhibitors
d. Sulfonamide

Question 3

when an Activated charcoal (carbon) –Toxins → prevent absorption of the toxin → blood

is an example of?

Answer 3

antidote for poisons

Question 4

when the EDTA–Ca++ → prevent Band keratopathy  thimerosal + EDTA

is an example of?

Answer 4

chelating agents (preservative)

Question 5

– drug that interacts with the receptor and elicit the expected desired effect

Answer 5

Agonist (D1)

Question 6

drug interacts with the receptor, preventing the action of the agonist→

Answer 6

Antagonist (D2)

Question 7

Types of Antagonism:

Answer 7

1. Pharmacologic
2. Physiologic
3. Chemical or antagonism by neutralization

Question 8

– antagonist that prevents agonist from acting upon its receptor site

Answer 8

Pharmacologic – antagonist

Question 9

antagonist that– competes with the agonist reversibly at the same receptor using Van der Waal’s bond (reversible)

Answer 9

Competitive Antagonist

Question 10

antagonist that – forms stronger & permanent covalent bond (irreversible) to receptor which can not be displaced even at high concentration of agonist

Answer 10

non-competitive –antagonist

Question 11

when 0.5% Tropicamide (mydriatic) → C/I angle closure glaucoma ← Pilocarpine (miotic)

is an example of?

Answer 11

Competitive Antagonist

Question 12

– drugs act independently on two different receptor sites

Answer 12

Physiologic Antagonist

Question 13

antagonist wherein- more receptors for the antagonist as compared to the agonist

Answer 13

Physiologic Antagonist

Question 14

antagonist – occurs when drugs combined with one another to form an inactive 3rd compound

Answer 14

Chemical or Antagonism by Neutralization

Question 15

antagonists that has drug-receptor interactions

Answer 15

Pharmacologic Antagonist

Physiologic Antagonist

Question 16

antagonist that has drug-non-receptor interaction

Answer 16

Chemical or Antagonism by Neutralization