Drug Distribution

Question 1

Factors that affect drug distribution:

Answer 1

1. Protein Barriers
2. Blood Flow
3. Tissue Permeability
4. Size of Organ
5. Presence of Receptor

Question 2

form that is active and reaches the site of action producing desired effect:

Answer 2

Free form or Unbound Form

Question 3

binds to albumin and remains in the blood circulation until excreted by the kidneys leading to drug termination of drug action

Answer 3

Bound Form

Question 4

– drug that have pass thru the hepatic microsomal enzymes (cP-450) and have undergone biotransformation into other form of drug either active or inactive (mostly) → EXCRETE

Answer 4

Metabolite

Question 5

(inactive) – requires metabolism to be activated

Answer 5

Pro-drug Form

Question 6

Increase in blood flow = ______ drug distribution

Answer 6

Increase

Question 7

has to pass the barriers

Ex. blood-brain barriers, blood-ocular barriers

Answer 7

Tissue Permeability

Question 8

the smaller the organ the ______ the drug is distributed

Answer 8

greater

Question 9

2 Blood Ocular Barriers:

Answer 9

• Blood-Aqueous Barrier
• Blood-Retinal Barrier

Question 10

barrier– between fenestrated ciliary body capillary (ciliary process) and tight junctions of non-pigmented epithelium of ciliary body

Answer 10

Blood-Aqueous Barrier

Question 11

barrier between fenestrated choriocapillary and tight junction of RPE

Answer 11

Blood-Retinal Barrier

Question 12

*Retinal & iris capillaries are non-______

Answer 12

Fenestrated

Question 13

choroid & ciliary body capillaries are ______ allowing diffusion of non-lipophilic substances.

Answer 13

Fenestrated