PHARM - Drug Targets and Action - Week 2 Flashcards
Define volume of distribution, and what it is not an indication of?
Indication of extent of distribution, but not location.
What is a composite of colume of distribution and clearance?
Half life, the time to stady state and dose interval
What four factors affect the concentration of of a drug in blood.
Absorption
Distribution
Metabolism
Excretion
Define pharmacokinetics.
Effects of the body on a drug
Define pharmacodynamics.
Effects of a drug on the body
Define an agonist.
A molecule that fits into a receptor to activate it.
Define an antagonist.
A molecule thats fits into a receptor to block its action.
Define an ion channel blocker.
A molecule that prevents permeation through the channel by blocking it.
Define an ion channel modulator.
A molecule that increases or decreases an ion channel’s permeation.
Define an enzyme inhibitor.
A molecule that fits into an enzyme to inhibit its normal reaction.
Define an enzyme false substrate.
A molecule that fits into an enzyme to result in an abnormal metabolite.
Define a prodrug.
A drug that once catalysed by a specific enzyme, will result in an active drug as the product/metabolite.
Outline the interaction between a false substrate and a transporter channel.
It results in the accumulation of an abnormal compound.
Define affinity.
A quantifiable measure of the molecular attraction to a receptor.
Describe the equation for the law of mass action.
[D] + [R] –(k+1)–> [DR] and
[D] + [R]