AED - Anti-inflammatory Agents I - Week 6 Flashcards
List 7 kinds of anti-inflammatory agents used in Australia and give an example for each.
Astringents - zince sulphate
Anti-histamines - antazoline
MCS - lodoxamide
Dual action MCS/AH - olopatadine
NSAIDs - ibuprofen
Corticosteroids - dexmethasone
Calcineurin/T-cell inhibitor - cyclosporine
Consider topical steroids. What is its potency and corneal penetration dependent on?
The formulation used - acetate vs phosphate vs alcohol
What kind of potency and penetration is ok for mild surface inflammation? What does this formulation minimise?
Low potency, low penetration
Minimises chance of steroid-induced IOP rise
High penetration and potency is essential for what eye disease? What formulation specifically?
Anterior uveitis
If required, write acetate on the Rx
Order the following by penetrance from highest to lowest:
Alcohol
Phosphate
Acetate
Acetate»_space; alcohol > phosphate
What is the general guideline for the use of ocular lubricants (4)?
Mild ocular surface irritation (including SPK)
Neurotrophic keratitis
Adjunct in severe inflammation
What is the general guideline for the use of astringent eye drops (1)?
Mucoid discharge in allergic surface disease
What is the general guideline for the use of antihistamine eye drops (1)?
Allergic eye disease (type I hypersensitivity)
What is the general guideline for the use of MCS eye drops (1)?
Allergic eye disease (type I hypelsensitivity)
What is the general guideline for the use of dual action MCS/AH eye drops (1)?
Allergic eye disease (type I hypersensitivity)
What is the general guideline for the use of NSAIDs for ocular conditions (5)?
Mild/moderate allergic eye disease and other surface inflammation (episcleritis)
Intra-operative inhibition of miosis
Post-operative inflammation/analgaesia
What is the general guideline for the use of corticosteroid eye drops (5)?
All types of moderate to severe ocular surface inflammation
HSV and HZO keratitis (not epithelial)
Anterior uveitis
Endophthalmitis (intravitreal)
What is the general guideline for the use of cyclosporine eye drops (5)?
Corneal graft
Uveitis
Scleritis
VKC
Dry eye
Are astringents safe in pregnancy, lactation, and children?
Yes to all three
Are antihistamines safe in pregnancy, lactation, and children?
Avoid use in pregnancy and lactation
Children are probably ok
Are MCS safe in pregnancy, lactation, and children?
Probably safe in all three
Are dual action MCS/AH safe in pregnancy, lactation, and children?
Probably safe in all three
Are NSAIDs safe in pregnancy, lactation, and children?
Caution/not recommended in pregnancy
Safe in lactation and children
Is cyclosporine safe in pregnancy, lactation, and children?
Caution/not recommended in pregnancy
Contraindicated in lactation