PHARM - Anti-Inflammatory Drugs II: The Arachidonic Acid Pathway and NSAIDS - Week 6 Flashcards
Name 5 things that inflammation can occur in response to.
Infection
Trauma
Chemicals
Heat
‘Danger’
What three protective mechanisms does inflammation convey?
Prevents infection
Clears damaged cells/debris
Facilitates healing
List the two main anti-inflammatory actions of NSAIDs.
Inhibition of vascular dilation
Inhibits synergism with other mediators that enhance leakiness
What three conditions can NSAIDs be used as an analgaesic?
Headache
Menstrual pain
Musculoskeletal pain
What is often the preferred NSAID for use as an anti-pyretic agent?
Paracetamol
List the three major chemical classes of NSAIDs.
Salicylates
Propionic acids
Acetic acids
What chemical class of NSAIDs does aspirin fall under?
Salicylates
What chemical class of NSAIDs does ibuprofen fall under?
Propionic acids
What is the mechanism of action of salicylates?
Irreversibly acetylates COX
What are the three main/common uses for aspirin?
Analgaesic
Antipyretic
Anti-thrombotic
Name three possible side effects of aspirin.
Reyes syndrome
Tinnitus
Uric acid retention
What is the mechanism of action of acetic acids?
Potent inhibitors of COX
Which chemical class of NSAIDs is used largely for long-term treatment of inflammatory conditions (like rheumatoid arthritis)?
Acetic acids
What is the major adverse effect of NSAIDs and when is it most common?
Inhibiting the normal regulatory role of prostanoids, most common when taken at high doses for long periods.
List three adverse effects of inhibiting prostanoids.
Increased chance of GI ulceration/bleeding
Increased bleeding time
Renal impairment