pharm 1 liner- repro and serotonin

Question 1

Its use can increase risk of endometrial and breast cancer, cause postmenopausal uterine bleeding, but can stabilize bone mineral loss

Answer 1

estrogen

Question 2

Antiestrogen drugs used for treatment of infertility in anovulatory women

Answer 2

clomiphene

Question 3

Selective estrogen receptor modulator most commonly used for the treatment of breast cancer

Answer 3

tamoxifen

Question 4

Selective estrogen receptor modulator used for prevention of osteoporosis and invasive breast cancer

Answer 4

raloxifene

Question 5

Common side effect of tamoxifen and clomiphene

Answer 5

hot flushes

Question 6

Two estradiol derivatives with higher oral bioavailability and longer half-lives that are primarily used as oral contraceptives

Answer 6

ethanol estradiol and mestranol

Question 7

Androgen receptor agonist used to treat hypogonadism and promote secondary sex characteristics

Answer 7

testosterone

Question 8

5 alpha-reductase inhibitor used for benign prostatic hyperplasia and male pattern baldness

Answer 8

finasteride

Question 9

Partial androgen agonist used for endometriosis and hereditary angioedema

Answer 9

danazol

Question 10

Androgen receptor antagonist used to treat prostate cancer

Answer 10

flutamide

Question 11

Androgen receptor antagonist used for hirsutism in females

Answer 11

cyproterone

Question 12

Location of serotonin type-1 (5HT-1) receptors

Answer 12

mostly in brain

Question 13

5HT-1A receptor partial agonist indicated for generalized anxiety disorder; due to longer onset of action, is less effective for acute anxiety

Answer 13

buspirone

Question 14

5HT-1D/1B agonist used for migraine headaches

Answer 14

sumatriptan and -triptans

Question 15

Ergot alkaloid indicated for migraine headaches

Answer 15

ergotamine

Question 16

Reason ergot alkaloids are contraindicated in pregnancy

Answer 16

uterine contractions

Question 17

Two adverse effects of ergot alkaloids

Answer 17

prolonged vasospasm and hallucinations resembling psychosis

Question 18

Two drugs that may be used off-label for ischemia and gangrene caused by ergot alkaloids overdose

Answer 18

nitroprusside, nitroglycerin

Question 19

Serotonin receptor responsible for serotonin syndrome

Answer 19

5HT2

Question 20

H1 antihistamine with 5HT2 antagonist activity that is mostly used for carcinoid tumor but may be used to treat serotonin syndrome

Answer 20

cyproheptadine

Question 21

Location of serotonin type-3 (5HT-3) receptors

Answer 21

GI tract, vomiting center of medulla

Question 22

5HT-3 antagonist used for the prevention of chemotherapy-induced nausea and vomiting

Answer 22

ondansetron and -setrons