Pharm 1 Liner- Anti-histamines and respiratory

Question 1

Class of endogenous substances that include histamine, serotonin, prostaglandins, and vasoactive peptides that work in autocrine or paracrine matter

Answer 1

Autocoids

Question 2

2 peptides that increase capillary permeability and edema

Answer 2

Bradykinin and histamine

Question 3

Tissue distribution of histamine H1 receptors

Answer 3

Smooth muscle and mast cells

Question 4

Tissue distribution of histamine H2 receptors

Answer 4

Stomach, heart, mast cells

Question 5

Tissue distribution of histamine H3 receptors

Answer 5

Nerve endings and CNS

Question 6

2 common side effects of 1st generation anti-histamine

Answer 6

Sedation, anticholinergic

Question 7

1st generation antihistamine that is highly sedating

Answer 7

Diphenhydramine

Question 8

1st generation antihistamine that is least sedating

Answer 8

Chlorpheniramine

Question 9

Major indication for H1 antihistamines

Answer 9

IgE mediated allergic reaction (allergic rhinitis, urticaria)

Question 10

Antihistamine that is indicated for allergies, motion sickness, and insomnia

Answer 10

Diphenhydramine

Question 11

Antihistamine with motion sickness as the only indication

Answer 11

Dimenhydrinate

Question 12

3 2nd generation antihistamines

Answer 12

Fexofenadine, loratidine, and cetirizine

Question 13

H2 antagonist that causes the most interactions with other drugs

Answer 13

Cimetidine

Question 14

Indication for H2 antagonists

Answer 14

Acid reflux disease, duodenal ulcer and PUD

Question 15

mechanism of action of cromolyn

Answer 15

prevent mast cell degranulation (by blocking opening of chloride channels)

Question 16

enzyme that theophylline inhibits

Answer 16

phosphodiesterase