FA-pathology Neoplasias

Question 1

What is the gene product of ALK and what is the associated gain of function neoplasm

Answer 1

Receptor tyrosine kinase; lung adenocarcinoma

Question 2

What is the gene production of BCR-ABL and what is the associated gain of function neoplasm

Answer 2

Tyrosine kinase; CML, ALL

Question 3

What is the gene production of BCL-2 and what is the associated gain of function neoplasm

Answer 3

Antiapoptotic molecule; follicular and diffuse large B cell lymphoma

Question 4

What is the gene production of BRAF and what is the associated gain of function neoplasm

Answer 4

Serine/threonine kinase; melanoma, nonhodgkin lymphoma, papillary thyroid carcinoma

Question 5

What is the gene production of c-KIT and what is the associated gain of function neoplasm

Answer 5

Cytokine receptor; gastrointestinal stromal tumor (GIST)

Question 6

What is the gene production of c-Myc and what is the associated gain of function neoplasm

Answer 6

Transcription factor; bri kit lymphoma

Question 7

What is the gene production of HER2/neu and what is the associated gain of function neoplasm

Answer 7

Receptor tyrosine kinase; breast and gastric carcinomas

Question 8

What is the gene production of JAK2 and what is the associated gain of function neoplasm

Answer 8

Tyrosine kinase; chronic myeloproliferative disorders

Question 9

What is the gene production of KRAS and what is the associated gain of function neoplasm

Answer 9

GTPase; colon cancer, lung cancer, pancreatic cancer

Question 10

What is the gene production of MYCL1 and what is the associated gain of function neoplasm

Answer 10

Transcription factor; lung tumor

Question 11

What is the gene production of MYCN and what is the associated gain of function neoplasm

Answer 11

Transcription factor; neuroblastoma

Question 12

What is the gene production of RET and what is the associated gain of function neoplasm

Answer 12

Receptor tyrosine kinase; MEN 2A and 2B, medullary thyroid cancer

Question 13

What is the gene production of APC and what is the associated loss of function neoplasm

Answer 13

Negative regulatory of beta-catenin/WNT pathway; colorectal cancer (associated with FAP0

Question 14

What is the gene production of BRCA1/BRCA2 and what is the associated loss of function neoplasm

Answer 14

DNA repair protein; breast, ovarian, and pancreatic cancer

Question 15

What is the gene production of CDKN2A and what is the associated loss of function neoplasm

Answer 15

P16, blocks G1 to S phase; melanoma, pancreatic cancer

Question 16

What is the gene production of DCC and what is the associated loss of function neoplasm

Answer 16

DCC (deleted in colon cancer); colon cancer

Question 17

What is the gene production of MEN1 and what is the associated loss of function neoplasm

Answer 17

Menin

Question 18

What is the gene production of PTEN and what is the associated loss of function neoplasm

Answer 18

Tyrosine phosphatase of PIP3; breast cancer, prostate cancer, endometrial cancer

Question 19

What is the gene production of Rb and what is the associated loss of function neoplasm

Answer 19

Retinoblastoma, osteosarcoma

Question 20

What is the gene production of TSC1 and what is the associated loss of function neoplasm

Answer 20

Hamartin protein; Tuberous sclerosis

Question 21

What is the gene production of TSC2 and what is the associated loss of function neoplasm

Answer 21

Tuberin protein; tuberous sclerosis

Question 22

What is the gene production of VHL and what is the associated loss of function neoplasm

Answer 22

Inhibits hypoxia inducible factor 1a; von nipple Lindau disease

Question 23

Detrusor overactivity leads to what?

Answer 23

Urge incontinance