Pharm 1 Liner- Autonomics Flashcards
Beta blockers with partial agonist activity, can bronchodilator and may have an advantage treating patients with asthma (2)
Pindolol, acebutolol
Indicated for symptomatic orthostatic hypotension
Midodrine
Antimuscarinic for prophylaxis of motion sickness
Scopolamine
Beta blockers effect on the heart in antianginal therapy (6)
Reduce heart rate, blood pressure, contractility, myocardial oxygen consumption, increase ejection time, and no change or increase end diastolic volume
Blocks alpha 1 and beta receptors and indicated for treatment of CHF
Labetalol and carvedilol
Its ability to vasoconstrict and increase blood pressure makes it useful as local decongestant and for the therapy of spinal shock (temporary maintenance of blood pressure)
Alpha 1 agonists
Treatment of myasthenia gravis and sometimes used prophylactically for organophosphate poisoning in chemical warfare
Pyridostigmine
Organophosphate, indicated for glaucoma but not used much clinically due to long duration of action
Echothiophate
Alpha 1a-selective blocker used for BPH
Tamsulosin
A non-selective beta blocker with alpha 1 blocking effect indicated for CHF
Carvedilol
Beta blockers are used for this type of angina attack
Classic (exertional) angina
Beta blockers should be used cautiously in (3)
Asthma (bronchospastic effects), diabetics (block signs of hypoglycemia), and peripheral vascular disease
Toxicity caused by this class of drugs is chars by DUMBELSS (diarrhea, urination, miosis, bronchoconstriction, excitation of skeletal muscle and CNS, lacrimation, salivation, sweating)
Cholinergic drugs
Indirect acting sympathomimetic, improves urinary continence in children and elderly with enuresis
Ephedrine
Short acting beta blocker that can be given parenterally, commonly used in hemodynamically unstable patients
Esmolol
Beta 1 agonist toxicity (2)
Sinus tachycardia and serious arrhythmia
Contraindications to use atropine (3)
Infants, closed angle glaucoma, prostatic hypertrophy
Its ability to increase heart rate makes it useful as adjunct therapy for acute herat failure and hypovolemia or septic shock
Beta 1 agonist
Muscarinic selective cholinomimetic used to diagnose asthma
Methacholine
Longer acting beta 2 agonist, indicated for prophylaxis of asthma
Slameterol
Alpha agonist indicated for nasal congestion, hypotension, and mydriasis induction
Phenylephrine
Indirect acting sympathomimetic, reuptake inhibitor, commonly abused, indicated for attention deficit disorder and weight reduction
Methaphetamine
Insecticide organophosphate
Malathion, parathion
Beta agonist used in acute CHF
Dobutamine and dopamine
Drug of choice for anaphylactic shock
Epinephrine
Anti muscarinic that produces mydriasis and cycloplegia
Atropine and anti-muscarinics
Irreversible, non-selective alpha-blocker indicated for pheochromocytoma
Phenoxybenzamine
Short acting beta 2 agonist, drug of choice for acute asthma
Albuterol
Selective beta 1 receptor blockers useful for treating cardiac conditions in patients with asthma (5)
Acebutolol, betaxolol, esmolol, atenolol, metoprolol (A BEAM)
Pneumonic for beta receptors
You have 1 heart (beta 1) and 2 lungs (beta 2)
This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention
Bethanechol
Atropine fever is the most dangerous effect and can be lethal in this population group
Infants
Selective alpha 1 blocker used for HTN, BPH, may cause first dose orthostatic Hypotension (3)
Prazosin, terazosin, doxazosin
Alpha 1 agonist toxicity
Hypertension
The most important cause of acute deaths in cholinesterase inhibitor toxicity
Respiratory failure
Beta 2 agonist adverse effect
Skeletal muscle tremor
Mechanism of action of atropine
Non-selective antimuscarinic
Beta 2 agonist used to suppress premature labor, but cardiac stimulatory effects may be hazardous to mother and fetus
Terbutaline
Reversible, non-selective alpha blocker indicated for pheochromocytoma
Phentolamine
Antimuscarinic that treats Parkinsonism and extrapyramidal disease
Benztropine
Alkaloid muscarinic that is very lipid soluble and used in glaucoma
Pilocarpine
Used in treatment of muscarinic symptoms in organophosphate overdose
Atropine
Cholinesterase inhibitor, intermediate duration of action, used off label for postoperative paralytic ileus and urinary retention
Neostigmine
Antimuscarinic indicated for overactive bladder muscle dysfunction
Oxybutynin
Side effects of beta blockers
Bradycardia, AB block, impotence, dyslipidemia, exacerbation of COPD
Cholinesterase inhibitor, short duration of action, used in diagnosis of myasthenia gravis
Edrophonium
Antimuscarinic that causes bronchodilation in asthma and COPD (2)
Ipatropium, tiotropium
Non-selective beta blocker that lacks local anesthetic activity, indicated for glaucoma
Timolol
Muscarinic used to treat dry mouth in Sjögren’s syndrome
Pilocarpine or cevimeline
Cholinesterase inhibitor, lipid soluble, indicated for atropine overdose and glaucoma
Physostigmine