autoantibodies for board review

Question 1

ANA

Answer 1

SLE, nonspecific

Question 2

Antid-dsDNA

Answer 2

SLE

Question 3

anti-Ro (anti-SSA)

Answer 3

sjogrens syndrome, inflammatory myopathies, SLE

Question 4

anti-la (Anti-SSB)

Answer 4

sjogrens syndrome, SLE

Question 5

anti-smith

Answer 5

SLE

Question 6

anti-nRNP/anti-U1-RNP

Answer 6

mixed connective tissue disease, SLE, diffuse sclerosis, limited sclerosis (CREST)

Question 7

anti-scl-70

Answer 7

scleroderma (diffuse)

Question 8

anti-jo-1

Answer 8

inflammatory myopathies, polymyositis, dermatomyositis

Question 9

anti-histone

Answer 9

drug induced lupus

Question 10

anti-centromere

Answer 10

esp limited scleroderma (CREST)

Question 11

anti-p62

Answer 11

primary biliary cirrhosis

Question 12

anti-sp100

Answer 12

primary biliary cirrhosis

Question 13

anti-smooth muscle antibody

Answer 13

autoimmune hepatitis

Question 14

anti-mitochondrial antibody

Answer 14

primary biliary cirrhosis

Question 15

anti-SRP

Answer 15

polymyositis, dermatomyositis

Question 16

anti-CCP

Answer 16

rheumatoid arthritis

Question 17

anti-tTG

Answer 17

celiac disease

Question 18

anti-eTG

Answer 18

celiac disease

Question 19

anti-actin

Answer 19

celiac disease, autoimmune hepatitis, gastric cancer

Question 20

cANCA

Answer 20

granulomatous with polyangitis (wagerers)

Question 21

pANCA

Answer 21

microscopic polyangiitis, churg-strauss, ulcerative colitis

Question 22

anti-nicotinic acetylcholine receptor

Answer 22

myasthenia gravis

Question 23

anti-thyroid peroxidase

Answer 23

hashimotos

Question 24

anti-TSH receptor

Answer 24

graves

Question 25

anti-platelet antibodies

Answer 25

ITP (immune thrombocytopenia)

Question 26

anitbasement membrane

Answer 26

good pasture syndrome