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BOARDS specific notecards > pharm 1 liner- blue high yield > Flashcards

pharm 1 liner- blue high yield Flashcards

1
Q

H1 antihistamine with 5HT2 antagonist activity that is mostly used for carcinoid tumor but may be used to treat serotonin syndrome

A

cyproheptadine

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2
Q

agent that is metabolized by alcohol dehydrogenase or microsomal ethanol-oxidizing system (MEOS) to acetaldehyde; displays zero order kinetics of elimination

A

ethanol

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3
Q

used for symptomatic treatment of thyrotoxicosis by blocking cardiac adverse effects

A

beta blockers such as propranolol and esmolol

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4
Q

side effect of menicillamine

A

hypersensitivity (rash), nephrotoxicity, myopathy, myelosuppresion

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5
Q

antidote for methotrexate toxicity

A

leucovorin

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6
Q

4 intermediate acting glucocorticoids

A

prednisone, prednisolone, methylprednisolone, trialcinolone

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7
Q

drug of choice indicated for familial or essential tremors

A

propranolol

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8
Q

a centrally acting anticholinergics useful for tremor and rigidity but have little effect on bradykinesia in patients with parkinson

A

benztropine

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9
Q

opioid receptor antagonist used to prevent alcohol abuse

A

naltrexone

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10
Q

dose-limiting toxicity of methotrexate

A

myelosuppresion

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11
Q

drug used concurrently with antineoplastics to reduce renal precipitation of urates

A

allopurinol

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12
Q

competes for alcohol dehydrogenase and is used in methanol or ethylene glycol poisoning

A

fomepizole, ethanol

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13
Q

gonadotropin-releasing hormone agonist that can be used to inhibit luteinizing hormone secretion and testosterone production in men with advanced prostate cancer

A

leuprolide

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14
Q

selective estrogen receptor modulator most commonly used for treatment of breast cancer

A

tamoxifen

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15
Q

antidote for opioid toxicity

A

naloxone (IV)

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16
Q

opioid antagonist that is given orally

A

naltrexone

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17
Q

CNS stimulate that acts by inhibiting reuptake of neurotransmitters; may cause pupil dilation, alter tactile sensation, irregular breathing and cardiac toxicity

A

cocaine

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18
Q

drug for treating malignant hyperthermia associated with drug-drug interaction between halogenated anesthetics and depolarizing blocker

A

dantrolene

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19
Q

2 anthracyclines that chelate DNA, form free radicals, and cause dose-limiting cardiotoxicity

A

daunorubicin, doxorubicin

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20
Q

side effect of nitroprusside

A

cyanide poisoning

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21
Q

long-acting opioids used in the management of withdrawal states

A

methadone, buprenorphine

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22
Q

opioids used for long-term maintenance from opioid withdrawal

A

methadone, buprenorphine

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23
Q

opioid receptor antagonist that is used to treat opioid intoxication, may cause more rapid and intense symptoms of withdrawal

A

naloxone

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24
Q

agent that is used to bind acrolein and prevent drug-induced hemorrhagic cystitis

A

meson

25
Q

irreversible, nonselective COX inhibitor that displays zero-order kinetics of elimination

A

aspirin

26
Q

selective estrogen receptor modulator used for prevention of osteoporosis and invasive breast cancer

A

raloxifene

27
Q

antidote for wilson’s disease (copper poisoning)

A

penicillamine

28
Q

the only local anesthetic with vasoconstrictive property, but due to abuse potential, only occasionally used for nasal surgery

A

cocaine

29
Q

treatment for drug-induced neuroleptic malignant syndrome

A

dantrolene

30
Q

antidote for acetaminophen poisoning

A

N-acetylcysteine

31
Q

iron chelator that is used to protect against anthracycline-induced cradiotoxicity

A

dexrazoxane

32
Q

side effect of tissue plasminogen activators

A

cerebral hemorrhage

33
Q

ergot type 2 dopamine receptor (D2) agonist, used as adjunct to improve motor function in parkinsons patients with fluctuations in clinical response

A

bromocriptine

34
Q

vitamin K dependent anticoagulant with zero order kinetics of elimination

A

warfarin (PT)

35
Q

recombinant human monoclonal antibody against human epidermal growth factor 2 (HER2) receptor; useful in breast cancer cells that overexposes HER2

A

trastuzumab

36
Q

side effect of acetaminophen

A

hepatotoxicity

37
Q

antidote used for warfarin toxicity

A

vitamin 1 and fresh frozen plasma

38
Q

serious side effect of selective serotonin reuptake inhibitors when used with other drugs such as monoamine oxidase inhibitors, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressants

A

serotonin syndrome

39
Q

serious side effect of cyclophosphamide and ifosamide due to generation of acrolein

A

hemorrhagic cystitis

40
Q

ergot dopamine agonist used to suppress prolactin release

A

bromocriptine

41
Q

antidote used for heparin toxicity

A

protamine sulfate

42
Q

antidote for TCA (tricycle antidepressants)

A

sodium bicarbonate (alkalinize plasma)

43
Q

antimuscarinic that treats parkinsonism and extrapyramidal disease

A

benztropine

44
Q

antidote for cyanide poisoning

A

nitrites, thiosulfate, hydroxocobalamin

45
Q

2 prodrugs, that after liver bioactivation, bind to N7 nitrogen of guanine and cross-link DNA

A

cyclophosphamide, ifosamide

46
Q

rare, but fatal side effect associated with combination of halogenated inhalation anesthetic and depolarizing blocker

A

malignant hyperthermia

47
Q

gonadotropin-releasing hormone analog used for infertility (pulsatile admin) or suppression of gonadotropin production (continuous administration)

A

leuprolide

48
Q

opioid antagonist that is given IV

A

naloxone

49
Q

three life-threatening side effects associated with tricyclic antidepressants

A

convulsions, cardiotoxicity, coma (3 Cs)

50
Q

antidote for methanol and ethylene glycol toxicity

A

fomepizole, ethanol

51
Q

antidote for benzodiazepine toxicity

A

flumazenil

52
Q

anti epileptic agent that exhibits zero order kinetics,c causes fetal hydantoin syndrome, and induces CYP450

A

phenytoin

53
Q

benzodiazepine antagonist used to treat benzodiazepine intoxication

A

fumazenil

54
Q

side effect of both warfarin and heparin

A

bleeding

55
Q

agent that inhibits xanthine oxidase and used to treat chronic gout

A

allopurinol, febuxostat

56
Q

antineoplastic folic acid analog that inhibits dihydrofolate reductase

A

methotrexate

57
Q

2 most commonly used glucocorticoids for cancer due to their lymphotoxin effects; may cause coshing-like symptoms

A

prednisone, prednisolone

58
Q

constant amount of drug metabolized per unit time

A

zero order kinetics

59
Q

antidote for tissue plasminogen activator (t-PA), streptokinase

A

aminocaproic acid

BOARDS specific notecards (42 decks)

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