Important Cancer Markers Flashcards
What is the normal function of BRCA1/2
DNA repair genes
What is the normal function of APC/beta-catenin
Want signaling pathway
What is the normal function of TP53
Genomic stability
What is the normal function of RB
Gi/S transition inhibitor
What is the normal function of WT1
Urogenital differentiation
What is the normal function of VHL
Ubiquitin ligase component
What is the normal function of RAS
GTP-binding protein
What is the normal function of MYC
Transcription factor
What is the normal function of ERBB1 (EGFR)
Receptor tyrosine kinase
What is the normal function of ERBB2 (HER2)
Receptor tyrosine kinase
What is the normal function of ABL
Nonreceptor tyrosine kinase
What is the normal function of BRAF
Ras signal transduction
What can mutations of RAS cause
Cholangiocarcinoma, pancreatic adenocarcinoma
What can mutations of MYC cause
Burkitt lymphoma
What can mutations of ERBB1 (EGFR) cause
Lung adenocarcinoma