Pathology of the Alimentary Tract III Flashcards

1
Q

What is the definition of Intestine stenosis?

A

intestine contains areas of blockage that prevents food moving through

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2
Q

What is intestinal atresia?

A

Intestine is closed or absent

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3
Q

What is megacolon?

A

abnormal dilation of the colon

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4
Q

What is Aganglionosis?

A

a blockage of the large intestine due to improper muscle movement in the bowel.

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5
Q

What can cause intestinal stenosis?

A

Compression via granulomas, abscesses, tumours

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6
Q

What is atresia coli?

A

colon is occluded

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7
Q

What is atresia ani?

A

anus is occluded

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8
Q

what is segmental atresia?

A

a segment of the bowel is either entirely missing or completely occluded due to a lack of epithelila development

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9
Q

What are the general causes of atresia?

A

malpositioning of the foetus, mechanical lesion to the vessel in a portion of the gut , vascular accidents

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10
Q

What is the usual cause of congenital megacolon?

A

A developmental lack of ganglion cells due to the myenteric plexus

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11
Q

What is the usual cause of acquired megacolon?

A

Can be secondary to atresia ani
* damage to the colonic innervation

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12
Q

What is the cause of agangliosis?

A

Congenital absence of ganglion
cells from the myenteric
(Auerbach’s) plexus or
submucosal (Meissner’s) plexus

more common in overo foals

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13
Q

What can cause generalised obstruction and impaction?

A
  • foreign bodies
  • copper/ zinc toxicosis
  • lead (common in cows ingesting batteries)
  • linear foreign bodies
    *
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14
Q

What three things can cause heavy impactions in horses?

A
  • heavy ascarid infections (ascardid is a parasite)
  • poor dentition (diets with high roughage)
  • ingested sand accumulating in the colon
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15
Q

What can cause narrowing of the intestinal lumen in horses?

A

can occur from fibrosis

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16
Q

What is Intussusception?

A

One segment of intestine becomes telescoped into the immediately distal segment of the intestine

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17
Q

What are the consequences of intestinal obstruction and impaction?

A

Death from -
* Toxemia
* Starvation
* Dehydration and emaciation
Gross lesions
* distended abdomen
* dilated bowel
* perforation

18
Q

What is the Intussuscipiens and Intussusceptum?

A

the *trapping *segment and the trapped segment

19
Q

What does causes Intussusception

A
  • altered mobility/ peristalsis
  • peritonitis/enteritis
  • foreign bodies/ masses
  • idiopathic
20
Q

What is an Eventration?

A

protrusion of the intestine through the abdominal wall or diaphragm

21
Q

What is a volvulus?

A

Twisting of the intestine along its mesenteric axis

22
Q

What is a torsion?

A

rotation of a tubular organ along its long axis

23
Q

How does strangulation by pedunculated lipomas occur?

A

Pedunculated lipomas wrap around the intestinal mesentry or the bowel
they may rotate around their pedicle

usually in horses

24
Q

What is an internal herniation?

A

Formed through a normal or pathological foramen in the abdominal cavity

  • e.g the Foramen of Winslow which is between the greater peritoneal sac
25
What is an external herniation?
a hernial sac (formed by a pouch of parietal peritoneum) which penetrates outside of the abdominal cavity
26
What can intestinal displacements lead to?
incarceration, obstruction, and ischemic necrosis
27
What causes non-inflammatory diarrhoea?
* pathogens disrupt the absorptive or secretory mechanisms of the enterocytes * No cell lysis * this usually effects more proximal portions of the bowel
28
What causes inflammatory diarrhoea?
Pathogens producing cytotoxins or are invasive and then activate cytokines that initiate inflammatory cascades generally effects the ileum, caecum or colon
29
What are the 5 mechanisms of inflammation of the intestine?
1. Malabsorption 2. Chloride hypersecretion 3. Exudation 4. Hypermotility 5. Cell damage and death
30
What are the 5 types of exudate caused by inflammation of the intestine?
* Atrophic/ Necrotic * Ulcerative * Lymphoplasmacytic * Granulomatous * Proliferative
31
What is the consequence of rotavirus?
Villous atrophy of enterocytes leading to diarrhoea
32
What in dogs and cats causes intestinal lesions?
Dogs- parvovirosis Cats- Panleukopaenia
33
What does clostridial enterotoxaemia cause in healthy animals?
necrotising/ haemorrhagic enterocolitis and toxaemia sudden death in well-nourished animals
34
How does lymphoplasmacytic enteritis occur? | causes inflammatory bowel disease
Infiltrates in the lamina propria villous atrophy and epithelial necrosis, crypt dilation can then evolve to a lymphoma
35
What causes Johnes' disease?
Mycobacterium avium this is a granulomatous inflammation in lamina propria, causes chronic wasting and diarrhoea
36
What does salmonelliosis cause?
Bacterial toxins -> Button ulcers
37
What causes proliferative enteritis in pigs?
* Lawsonia intracellularis * Hyperplasia of enterocytes, resulting in distortion of the normal architecture * bacteria are present in the apical cytoplasm of the enterocytes
38
What are some examples of epithelial tumours found in the intestine?
Polyps, adenomas, adenocarcinomas,
39
Where do leimyomas and leiomyosarcomas arise from?
They arise from the tunica muscularis
40
Where do GISTS (gastrointestinal stromal tumours) arise from?
They arise from interstitial cells of cajal * they are primarily found in dogs and horses
41
Where can visceral mast cell tumours be seen?
can be seen in the alimentary system, mostly in cats but also in dogs