Brachyspira Flashcards

1
Q

How would you culture brachyspira?

A
  • Fastidious anaerobe broth
  • Blood agar-> culture at 37 degrees, anaerobically for up to 2 weeks
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2
Q

Where does brachyspira multiply?

A

In the crypts of lieberkuhn, this causes erosion and necrosis of the mucosa

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3
Q

What samples could you take for a brachyspira diagnosis?

A
  • Faeces
  • Blood
  • Deep mucosa intestianl scrape
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4
Q

What disease does brachyspira cause in poultry?

A

Avian intestinal spirochaetes
* mainly a problem in layers

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5
Q

What is intestinal spirochaetosis?

A

Bacteria intestinal disease that mainly effects the caeca and colo-rectum

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6
Q

When is intestinal spirochaetosis usually observed?

A

Often observed just as birds are about to reach peak egg productivity
* leads to reduced productivity

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7
Q

How do birds become infected with intestinal spirochaetosis?

A

Poultry become infected via the faecal-oral route

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8
Q

What is the clinical manifestation of avian spirochaetosis?

A
  • Depression of egg production
  • Production of faecally stained eggs
  • Reduced mean egg weight
  • Increased morbidity/ Mortality
  • Reduced carotenoid in eggs
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9
Q

What is the gross pathology of avian spirochaetosis

A
  • Caecal atrophy
  • Petechial haemorrhage
  • Ilium dilation
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10
Q

What is the histopathology of avian spirochaetes?

A
  • Moderate lymphohistiocytic infiltration
  • Mild crypt hyperplasia
  • Accumulation of eosinophillic material in crypts
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11
Q

What brachyspira species causes swine dysentry?

A

Brachyspira hyodysenteriae

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12
Q

What does swine dysentry cause?

A

Severe inflammation of the large intestine with bloody mucous diarrhoea

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13
Q

How long does brachyspira survive in the environment?

A

Brachyspira can survive for up to 7 weeks in a cold moist environment

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14
Q

What is the usual incubation period for swine dysentry field cases?

A

7 to 14 days

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15
Q

What is the economic significance of swine dysentry?

A

High cost of disease is associated with low mortality and high morbidity

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16
Q

What are the clinical signs of swine dysentry?

A
  • Sloppy diarrhoea
  • Diarrhoea is initially light brown with a ‘jelly-like’ mucus and becomes watery
  • Tail twitching
  • Hollowing of the flanks with poor growth
  • Partial appetite loss
  • Slight skin reddening
17
Q

How do pigs become infected with swine dysentry?

A
  • Ingestion of infected faeces
  • Usually spread by carrier pigs that shed the organism in faeces for long periods
  • Mechanically infects faeces via equipment
  • Can also be spread via flies, mice, birds and dogs
18
Q

How would you diagnose brachyspira?

A
  • Clinical signs
  • PM examination
  • Lab testing on faecal smears
19
Q

Why is Brachyspira now more common in pigs?

A
  • Ban on growth promoting antibiotics
  • Increase in outdoor rearing
20
Q

Name 5 ways you could diagnose brachyspira?

A
  1. ELISA testing
  2. PCR
  3. LAMP
  4. WGS
  5. Culture
21
Q

Name 3 potential treatments for brachyspira

A
  1. Tiamulin
  2. Tylosin
  3. Tylvalosin
22
Q

Name two non-pathogenic brachyspira species

A
  • B.murdochii
  • B.innocens
23
Q

What three Brachyspira subtypes cause Avian Intestinal Spirochaetosis?

A
  1. B.pilosicoli
  2. B.intermedia
  3. B.alvinipulli
24
Q

When is intestinal spirochaetosis usually observed?

A

Often observed just as eggs are about to reach peak egg productivity
This leads to reduced productivity
Poultry are infected via the faecal-oral route

25
Q

What are the clinical signs of swine dysentry?

A
  • Sloppy diarrhoea
  • Tail twitching
  • Hollowing of the flanks
  • Partial appetite loss
  • Skin reddening
26
Q

How do pigs become infected with swine dysentry?

A
  • Ingestion of infected faeces
  • Spread by carrier pigs that shed the organisms in faeces
  • Mechanically via equipment
  • Spread via flies, mice, dogs
27
Q

How would you diagnose swine dysentry?

A
  • Post-Mortem examination
  • Lab testing on faecal smears
  • Isolation and identification of B.hyodysenteriae
  • Serology
  • Biochem testing
28
Q

What does swine dysentry have to be distinguished against?

A

Colitis

29
Q

What are the vaccines for brachyspira?

A

There are curently no vaccines for brachyspira

30
Q

What are the clinical manifestations of avian spirochaetosis?

A
  • Decreased carotenoid
  • Weak chicks
  • FRofthy droppings
  • faecally stained eggs
  • change in shell colour
31
Q

What are the predisposing factors for swine dysentry?

A
  • Stress resulting from feed change
  • Poor sanitation and wet pens
  • Overcrowding