Parvovirus, Papovirus, Adenovirus Flashcards
Parvovirus, Papovirus, and Adenovirus are what type of virus?
DNA virus
The only single-stranded DNA virus
Parvovirus
Determine the virus:
- Single stranded
- Naked
- Icosahedral
- Linear
Parvovirus
Determine the virus:
- Double-stranded
- Naked
- Icosahedral
Adenovirus and PaPoVavirus
PaPoVavirus ay circular
Parvovirus
Discovered by and what year?
Yvonne Cossart in 1970s
Parvovirus
Comes from the Latin word “____” which means?
“parvum” means small
the smallest DNA animal virus
Parvovirus
Parvovirus
Family:
Common name:
Virus:
- Parvoviridae
- Parvovirus
- Parvovrisu B-19
Parvovirius: Characterisitc
The only known human parvovirus
Parvovirus B-19
Parvovirus
What is the transmission
Close contact, probably respiratory
Parvovirus
detection
- Serology
- polymerase chain reaction
(PCR) - Histology
Parvovirus`
treatment
supportive
wow
Parvovirus`
Prevention
Avoid contact
Parvovirus: Viral Replication
- Virion ____ to the host cell
Attaches
Parvovirus: Viral Replication
2.virion ____ and its DNA is ____
- Penetrates
- Uncoated
Parvovirus: Viral Replication
3.Early transcription and translation of ____
mRNA
enzymes are synthesiez
Parvovirus: Viral Replication
4.Late ____
5.Late ____
- Transcription (DNA is replicated)
- Translation (capsid proteins are synthesized)
Parvovirus: Viral Replication
6.Virions ____
Mature
Parvovirus: Viral Replication
7.Virions are ____
Released
for viral multiplication and infection
what is the disease related to parvovirus?
ERYTHEMA INFECTIOSUM or FIFTH DISEASE
ERYTHEMA INFECTIOSUM or FIFTH DISEASE
Diagnostic characteristic
“slapped” cheeks (blood vessels on cheeks would collpase
affects the endothelial cells
ERYTHEMA INFECTIOSUM or FIFTH DISEASE
what does fifth disease causes?
- Aplastic Crisis
- Hydrops fetalis or hemolytic disease of newborns
ERYTHEMA INFECTIOSUM or FIFTH DISEASE
systemic lupus erythematosus
Malar Rash
ERYTHEMA INFECTIOSUM or FIFTH DISEASE
Blood picture would still exhibit normocytic and normochromic but RBC precursors will exhibit a sickle-shape which may develop sickle-cell
anemia or hemolytic anemia
Aplastic crisis
ERYTHEMA INFECTIOSUM or FIFTH DISEASE
Aplastic Crisis:
Rbc will not reach the?
120 maturation days
ERYTHEMA INFECTIOSUM or FIFTH DISEASE
50% of childbearing age are suisceptible of this disease and if it happend it causes miscarriages (during trimester)
Hydrops fetalis or hemolytic disease of newborns
ERYTHEMA INFECTIOSUM or FIFTH DISEASE
mode of transmission?
- Repiratory routes (inhalation via droplets)
- Blood products
- Factor VIII and IX concentrates
- Transplacental (vertical - mother to baby)
Parvovirus: Pathogenesis
If the virus enters through the respiratory tract, it may undergo 2 paths
- Local replication
- Replication in erythroid precursor cells in the bone marrow
Parvovirus: Pathogenesis
local replication and replication in Erythroid precursor cells in BM leads to ?
Viremia
Parvovirus: Pathogenesis
what is viremia?
Virus in the blood
Parvovirus: Pathogenesis
Viremia →
clue 2 paths
- VIral replication in upper repiratory tract
- Rash and arthralgia (muscle pain) (Erythemia infectiosum)
Parvovirus: Pathogenesis
erythroid precursor
cells in the bone marrow →
3 paths
- Viremia (previous pathway)
- Normal host
- Host with chronic hemolytic anemia (or immunocompromised hosts)
Parvovirus: Pathogenesis
what will now happen to normal host?
slight decreased Hgb level (slight anemia)
not need any intervention
Parvovirus: Pathogenesis
what will happen to host with chronic hemolytic anemia (immunocompromised hosts)
affect
their organs or result to chronic anemia
Parvovirus
the entry post is also the?
exit point
Parvovirus
how to acquire and infect other of the virus
Inhalation and exhalation
Parvovirus
Once replication is done in the upper respiratory tracts what will happen?
manifestation will showL:
- Slapped cheeks
- Rash on the shoulder or other area of skin
- Joint pain (arthralgia)
Parvovirus
does aplastic crisis in the bone marrow (femur) can happen if its replicated?
yes, it make kulang of RBC production or they hindi mature enough
Parvovirus: Clinical Picture
From the start of infection, the aplastic crisis may coincide
with malais, what day?
8th day
Parvovirus: Clinical Picture
signs and symptoms may not be present. what day
0-6th day
Parvovirus: Clinical Picture
2nd-4th day what can happen
minute symptoms may be
experienced
Parvovirus: Clinical Picture
when is the actual onset of symptoms, which will start the virion increase
6th day
Parvovirus: Clinical Picture
Once the viremia starts to drop, IgM will increase , what day
10th day
10-12 day
Parvovirus: Clinical Picture
Immediately after viremia, when the virions are at its lowest point, IgG will then
increase—usually starting on ?
16th day
However, once
IgG appears, rash and arthralgia may appear along with it.
Diagnosis for Parvovirus
- Serologic and DNA tests
- Diagnosed by presence of IgM (acute parvovirus)
- PCR or viral DNA from blood sample or in case of fetus from amniotic fluid
What are the other viruses that is included in the PaPoVavirus
- Papilloma (wart) viruses
- Polyomavirus of mice
- Vacuolating (Simian virus 40, SV40)
PaPoVavirus: Features
Kbp for polyoma and papilloma
- 5 kbp
- 8 kbp
PaPoVavirus envolped or not?
Nonenveloped or Naked
size and shape of PaPoVavrius
44 to 55 nm icosahedral symmetry
Transcriptional “____” first defined for papovaviruses
enhancers
what does papovavirus use to replicate the genome
clue: an enzyme
host cell DNA polymerase
PaPoVa: Papilloma virus
give the capsomeres and capsid proteins (major and minor_
- 72 capsomers
- 2 capsid proteins—1 major (L1 ) and
1 minor (L2)
PaPoVa: Papilloma virus
Undergoes ____ for squamous epithelial cell resulting to a manifestation of warts
tropism
PaPoVa: Papilloma virus
Common warts
Verrucae vulgaris
PaPoVa: Papilloma virus
Plantar warts
Verrucae plantaris
PaPoVa: Papilloma virus
Flat warts
Verrucae plana
PaPoVa: Papilloma virus
Family:
Commona Name:
Virus:
- Papovaviridae
- Papilomavirus
- Human papiloma virus (HPV)
PaPoVa: Papilloma virus
transmission
- Direct contact
- sexual contact for genital warts
PaPoVa: Papilloma virus
Site of latency
Epithelial tissue