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Parvovirus, Papovirus, Adenovirus Flashcards

1
Q

Parvovirus, Papovirus, and Adenovirus are what type of virus?

A

DNA virus

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2
Q

The only single-stranded DNA virus

A

Parvovirus

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3
Q

Determine the virus:
- Single stranded
- Naked
- Icosahedral
- Linear

A

Parvovirus

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4
Q

Determine the virus:
- Double-stranded
- Naked
- Icosahedral

A

Adenovirus and PaPoVavirus

PaPoVavirus ay circular

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5
Q

Parvovirus

Discovered by and what year?

A

Yvonne Cossart in 1970s

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6
Q

Parvovirus

Comes from the Latin word “____” which means?

A

“parvum” means small

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7
Q

the smallest DNA animal virus

A

Parvovirus

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8
Q

Parvovirus

Family:
Common name:
Virus:

A
  • Parvoviridae
  • Parvovirus
  • Parvovrisu B-19
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9
Q

Parvovirius: Characterisitc

The only known human parvovirus

A

Parvovirus B-19

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10
Q

Parvovirus

What is the transmission

A

Close contact, probably respiratory

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11
Q

Parvovirus

detection

A
  • Serology
  • polymerase chain reaction
    (PCR)
  • Histology
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12
Q

Parvovirus`

treatment

A

supportive

wow

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13
Q

Parvovirus`

Prevention

A

Avoid contact

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14
Q

Parvovirus: Viral Replication

  1. Virion ____ to the host cell
A

Attaches

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15
Q

Parvovirus: Viral Replication

2.virion ____ and its DNA is ____

A
  • Penetrates
  • Uncoated
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16
Q

Parvovirus: Viral Replication

3.Early transcription and translation of ____

A

mRNA

enzymes are synthesiez

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17
Q

Parvovirus: Viral Replication

4.Late ____
5.Late ____

A
  • Transcription (DNA is replicated)
  • Translation (capsid proteins are synthesized)
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18
Q

Parvovirus: Viral Replication

6.Virions ____

A

Mature

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19
Q

Parvovirus: Viral Replication

7.Virions are ____

A

Released

for viral multiplication and infection

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20
Q

what is the disease related to parvovirus?

A

ERYTHEMA INFECTIOSUM or FIFTH DISEASE

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21
Q

ERYTHEMA INFECTIOSUM or FIFTH DISEASE

Diagnostic characteristic

A

“slapped” cheeks (blood vessels on cheeks would collpase

affects the endothelial cells

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22
Q

ERYTHEMA INFECTIOSUM or FIFTH DISEASE

what does fifth disease causes?

A
  • Aplastic Crisis
  • Hydrops fetalis or hemolytic disease of newborns
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23
Q

ERYTHEMA INFECTIOSUM or FIFTH DISEASE

systemic lupus erythematosus

A

Malar Rash

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24
Q

ERYTHEMA INFECTIOSUM or FIFTH DISEASE

Blood picture would still exhibit normocytic and normochromic but RBC precursors will exhibit a sickle-shape which may develop sickle-cell
anemia or hemolytic anemia

A

Aplastic crisis

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25
Q

ERYTHEMA INFECTIOSUM or FIFTH DISEASE

Aplastic Crisis:

Rbc will not reach the?

A

120 maturation days

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26
Q

ERYTHEMA INFECTIOSUM or FIFTH DISEASE

50% of childbearing age are suisceptible of this disease and if it happend it causes miscarriages (during trimester)

A

Hydrops fetalis or hemolytic disease of newborns

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27
Q

ERYTHEMA INFECTIOSUM or FIFTH DISEASE

mode of transmission?

A
  • Repiratory routes (inhalation via droplets)
  • Blood products
  • Factor VIII and IX concentrates
  • Transplacental (vertical - mother to baby)
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28
Q

Parvovirus: Pathogenesis

If the virus enters through the respiratory tract, it may undergo 2 paths

A
  • Local replication
  • Replication in erythroid precursor cells in the bone marrow
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29
Q

Parvovirus: Pathogenesis

local replication and replication in Erythroid precursor cells in BM leads to ?

A

Viremia

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30
Q

Parvovirus: Pathogenesis

what is viremia?

A

Virus in the blood

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31
Q

Parvovirus: Pathogenesis

Viremia →

clue 2 paths

A
  • VIral replication in upper repiratory tract
  • Rash and arthralgia (muscle pain) (Erythemia infectiosum)
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32
Q

Parvovirus: Pathogenesis

erythroid precursor
cells in the bone marrow →

3 paths

A
  • Viremia (previous pathway)
  • Normal host
  • Host with chronic hemolytic anemia (or immunocompromised hosts)
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33
Q

Parvovirus: Pathogenesis

what will now happen to normal host?

A

slight decreased Hgb level (slight anemia)

not need any intervention

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34
Q

Parvovirus: Pathogenesis

what will happen to host with chronic hemolytic anemia (immunocompromised hosts)

A

affect
their organs or result to chronic anemia

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35
Q

Parvovirus

the entry post is also the?

A

exit point

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36
Q

Parvovirus

how to acquire and infect other of the virus

A

Inhalation and exhalation

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37
Q

Parvovirus

Once replication is done in the upper respiratory tracts what will happen?

A

manifestation will showL:
- Slapped cheeks
- Rash on the shoulder or other area of skin
- Joint pain (arthralgia)

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38
Q

Parvovirus

does aplastic crisis in the bone marrow (femur) can happen if its replicated?

A

yes, it make kulang of RBC production or they hindi mature enough

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39
Q

Parvovirus: Clinical Picture

From the start of infection, the aplastic crisis may coincide
with malais, what day?

A

8th day

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40
Q

Parvovirus: Clinical Picture

signs and symptoms may not be present. what day

A

0-6th day

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41
Q

Parvovirus: Clinical Picture

2nd-4th day what can happen

A

minute symptoms may be
experienced

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42
Q

Parvovirus: Clinical Picture

when is the actual onset of symptoms, which will start the virion increase

A

6th day

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43
Q

Parvovirus: Clinical Picture

Once the viremia starts to drop, IgM will increase , what day

A

10th day

10-12 day

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44
Q

Parvovirus: Clinical Picture

Immediately after viremia, when the virions are at its lowest point, IgG will then
increase—usually starting on ?

A

16th day

However, once
IgG appears, rash and arthralgia may appear along with it.

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45
Q

Diagnosis for Parvovirus

A
  • Serologic and DNA tests
  • Diagnosed by presence of IgM (acute parvovirus)
  • PCR or viral DNA from blood sample or in case of fetus from amniotic fluid
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46
Q

What are the other viruses that is included in the PaPoVavirus

A
  • Papilloma (wart) viruses
  • Polyomavirus of mice
  • Vacuolating (Simian virus 40, SV40)
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47
Q

PaPoVavirus: Features

Kbp for polyoma and papilloma

A
  • 5 kbp
  • 8 kbp
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48
Q

PaPoVavirus envolped or not?

A

Nonenveloped or Naked

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49
Q

size and shape of PaPoVavrius

A

44 to 55 nm icosahedral symmetry

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50
Q

Transcriptional “____” first defined for papovaviruses

A

enhancers

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51
Q

what does papovavirus use to replicate the genome

clue: an enzyme

A

host cell DNA polymerase

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52
Q

PaPoVa: Papilloma virus

give the capsomeres and capsid proteins (major and minor_

A
  • 72 capsomers
  • 2 capsid proteins—1 major (L1 ) and
    1 minor (L2)
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53
Q

PaPoVa: Papilloma virus

Undergoes ____ for squamous epithelial cell resulting to a manifestation of warts

A

tropism

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54
Q

PaPoVa: Papilloma virus

Common warts

A

Verrucae vulgaris

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55
Q

PaPoVa: Papilloma virus

Plantar warts

A

Verrucae plantaris

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56
Q

PaPoVa: Papilloma virus

Flat warts

A

Verrucae plana

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57
Q

PaPoVa: Papilloma virus

Family:
Commona Name:
Virus:

A
  • Papovaviridae
  • Papilomavirus
  • Human papiloma virus (HPV)
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58
Q

PaPoVa: Papilloma virus

transmission

A
  • Direct contact
  • sexual contact for genital warts
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59
Q

PaPoVa: Papilloma virus

Site of latency

A

Epithelial tissue

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60
Q

PaPoVa: Papilloma virus

Oncogenic

A

Cervical and penile cancer (especially HPV types 16 and 18–for cervical canver onli)

61
Q

PaPoVa: Papilloma virus

Cervical cancer is cause by?

A

HPV - 16 and 18

62
Q

PaPoVa: Papilloma virus

cervical cancer is the?

A

Squamous cell cancer of the cervix

63
Q

PaPoVa: Papilloma virus

HPV-16 and HPV-18 can also manifest as?

A

vulvar cancer or penile cancer

fuki and penis

64
Q

PaPoVa: Papilloma virus

warts present in the anal or genital area and is mainly caused by
HPV-6, and HPV-11

A

Condylomata acuminata (anogenital warts)

65
Q

PaPoVa: Papilloma virus

Condylomata acuminata (anogenital warts) is caused by what type of HPV

A

HPV-6, and HPV-11

66
Q

PaPoVa: Papilloma virus

Disorder:
HPV 1, 2, and 4

A

Plantar and common warts

67
Q

PaPoVa: Papilloma virus

Plantar and common warts can be removed through?

A

Electrocautery

68
Q

PaPoVa: Papilloma virus

HPV types:
skin cancer

A

HPV 5 and 8

69
Q

PaPoVa: Papilloma virus

HPV type:
common warts

70
Q

PaPoVa: Papilloma virus

HPV Types:
Genital warts and Respiratory papilloma

A

HPV 6 and 11

71
Q

PaPoVa: Papilloma virus

Disorder:
HPV 16, 18, 31, 33, 35, 45, and 56

A

Anogenital malignancies

16 and 18 most important

72
Q

PaPoVa: Papilloma virus

Diagnosis

A

 Serology
 PCR- DNA
 Biopsy

73
Q

PaPoVa: Papilloma virus

Treatment

A
  • Surgery
  • Laser
  • Cryosurgery
  • Topical: Podophyllin and Idoxuridine (not common)
  • electrocautery
74
Q

PaPoVa: Polyoma virus

Murine polyomavirus was isolated by and what year

A

Ludwig Gross in 1953

75
Q

PaPoVa: Polyoma virus

where did the murine polyomavirus was isolated?

A

Leukemia in mice

76
Q

PaPoVa: Polyoma virus

Named polyomavirus because it caused

A

solid tumors at multiple sites

77
Q

PaPoVa: Polyoma virus

2 virus

A
  • BK virus [BKV]
  • JC virus [JCV]
78
Q

PaPoVa: Polyoma virus

Site of latency

79
Q

PaPoVa: Polyoma virus

Treatment

A

Supportive; decrease immune
suppression

80
Q

PaPoVa: Polyoma virus

Prevention

A

Avoid contact with virus; prevention of
acquisition of virus unlikely

81
Q

PaPoVa: Polyoma virus

isolated by Gardner et al in 1971 from urine of patient after
kidney transplant

A

BK VIRUS (BKV) or HUMAN POLYOMAVIRUS 1

82
Q

PaPoVa: Polyoma virus

who isolated BKV and what year

A

Gardner et al in 1971

et al amputa

83
Q

PaPoVa: Polyoma virus

BK VIRUS (BKV) or HUMAN POLYOMAVIRUS 1 causes?

A

Renal Disease

84
Q

PaPoVa: Polyoma virus

BK VIRUS (BKV) or HUMAN POLYOMAVIRUS 1 are common in?

A

immunosuppressed kidney transplant patients

85
Q

PaPoVa: Polyoma virus

representaion of BKV to a children

A

Mild respiratory disease

86
Q

PaPoVa: Polyoma virus

BKV was isolated from?

A

Various tumors

87
Q

PaPoVa: Polyoma virus

Isolated by Padget et al in 1971 from brain tissue

A

JC VIRUS (JCV) or HUMAN POLYOMAVIRUS 2

88
Q

PaPoVa: Polyoma virus

who isolated, what year and where the JCV

A
  • Padget et al
  • in 1971
  • brain tissue
89
Q

PaPoVa: Polyoma virus

since JCV is isolated from the brain tissue, what can you infer about how it affect the human

A

Affects the CNS, specifically the brain

mag think ka nga

90
Q

PaPoVa: Polyoma virus

JCV or Human polyomavirus causes what

A

Progressive Multifocal Leukoencephalopathy
(PML)

91
Q

PaPoVa: Polyoma virus

JCV Progressive Multifocal Leukoencephalopathy (PML) involves a rare disease that affects the CNS

A

plaques of
demyelination/inflammation in the CNS

92
Q

PaPoVa: Polyoma virus

PML:
____ from these lesions are infected with JCV

A

Oligodendrocytes

93
Q

PaPoVa: Polyoma virus - pathogenisis

TOF

type of virus depends on their route of infection

94
Q

PaPoVa: Polyoma virus - pathogenisis

Generally, when the virus is inoculated in the respiratory
tract, what happens?

A

Multiply in the same area

95
Q

PaPoVa: Polyoma virus - pathogenisis

Multiplication in respiratory tract →

A

primary viremia

96
Q

PaPoVa: Polyoma virus - pathogenisis

after primary viremia, when there is a multiplication in kidney what will happen after

A

Transient secondary viremia

97
Q

PaPoVa: Polyoma virus - pathogenisis

Secondary viremia occure in immunocompetent

A

virus will remain latent indefinitely the kidneys

basically - inactive

98
Q

PaPoVa: Polyoma virus - pathogenisis

when it is latent in the kidneys but the immune system fluctuates and made them immunodeficient what will happen

A

Reactivation of Virus

99
Q

PaPoVa: Polyoma virus - pathogenisis

what are the 2 paths for reactivation?

A
  • BKV multiplies in Urinary tract
  • JCV viremia
100
Q

PaPoVa: Polyoma virus - pathogenisis

BKV multiplies in Urinary tract →

A

viruria and possible hemorrhagic cystitis

viruria - virus is present

presence of virus detected by RT-PCR

101
Q

PaPoVa: Polyoma virus - pathogenisis

JCV viremia →

A

Affects the CNS, will cause PML

102
Q

PaPoVa:

VACUOLATING VIRUS other name

103
Q

PaPoVa: Vacuolating

hawk

r

104
Q

PaPoVa: Vacuolating

TOF

Ubiquitous in humans

A

T

Ubiquitous = present

105
Q

PaPoVa: Vacuolating

TOF
Ubiquitous in humans, but have NOT BEEN ASSOCIATED
WITH DISEASE

106
Q

PaPoVa: Vacuolating

Reside in the?

A

BrAIIINN

zombies phat ass

107
Q

PaPoVa: Vacuolating

have been associated with?

A

rare encephalopathy in immunocompromised individuals

108
Q

PaPoVa: Vacuolating

isolated by and in what year

A

Sweet and Hilleman in 1960

109
Q

PaPoVa: Vacuolating

Isolated by Sweet and Hilleman in 1960 in

A

primary monkey
kidney cells cultures

110
Q

PaPoVa: Vacuolating

primary monkey
kidney cells cultures being used to grow?

A

Sabin OPV Vaccine

111
Q

Adenovirus

Name originates from Greek word, which means?

A

“adenas” which means
gland

112
Q

Adenovirus

site from which were initially isolated

113
Q

Adenovirus

facilitate binding onto host

A

Fibers protruding from capsid

114
Q

Adenovirus

All human serotypes are included in a single genus within the
family ____

A

Adenoviridae

115
Q

Adenovirus

Latent infection in

A
  • tonsils
  • adenoids
116
Q

Adenovirus

Outbreaks mostly occur in

A
  • military recruits
117
Q

Adenovirus

Transmissio

A

Respiratory, fecal-oral, and direct
contact (eye

118
Q

Adenovirus

Site of Latency

A

Replication in oropharynx

119
Q

Adenovirus

Prevention

A

Vaccine (adenovirus serotypes 4 and
7)

120
Q

Adenovirus

All human Adenoviruses share this common group-specific antigen

A

Cross reactive protein- HEXON

121
Q

Adenovirus

TOF

print specific antigens are important in serotyping

A

F (TYPE not PRINT)

122
Q

Adenovirus

isolated in what year and from?

A
  • 1935
  • Human adenoid tissue
123
Q

Adenovirus

how many antigenic types were isolated from human and animals?

A

49 distinct antigenic types

124
Q

Adenovirus

Spread by?

A

o Direct contact
o Respiratory droplets
o Fecal-oral

125
Q

Adenovirus

Infect and replicate on?

A

Epithelial cells of:
- Pharynx
- Conjunctiva
- Urinary bladder
- Small intestine

126
Q

Adenovirus

The virus has a tendency to become latent in?

A

lymphoid tissue

127
Q

Adenovirus

when latent, how it can be reactivated?

A

by immunosuppression

128
Q

Adenovirus

portal of entry or first infection

A

eye and upper resipartory

129
Q

Adenovirus

eye and upper resipartory →

A

upper respiratory

130
Q

Adenovirus

Upper respiratory →

A

Lower respiratoy or Gastrointestinal

131
Q

Adenovirus

Lower respiratoy or Gastrointestinal →

A

lymph nodes

132
Q

Adenovirus

when in lymph nodes, whAT happens to the virus?

A

becomes latent, but if immucompromised will activate

133
Q

Adenovirus

Lymph node →

A

undergo viremia

134
Q

Adenovirus

Viremia →

A
  • Skin
  • Multiple organs

Manifestation

135
Q

Adenovirus

Skin and multiple organs →

A

Resolution or latency

136
Q

Adenovirus

no.1 cause of?

A

Viral conjunctivitis

137
Q

Adenovirus

Serotype:
Acute Respiratory Disease (ARD)

A

Serotype 3,4,7,21

138
Q

Adenovirus

Disease:
Stereotype 8,19

A

epidemic Keratoconjunctivitis

139
Q

Adenovirus

Serotype:
Hemorrhagic Cystitis

A

Serotype 11 and 21

140
Q

Adenovirus

Disease:
Serotype 40 and 41

A

Infantile Gastroenteritis

141
Q

ADENOVIRUS

STUDY THE PATIENT POPULATION

A

di naman daw to need kabisaduhin, pero ikaw bahala buhay mo naman yan kaya mo nayan ang laki mong bulas sa mundo

142
Q

Adenovirus

Virus particle by Electron microscopy can be detected by direct examination of

A

Fecal extract

143
Q

Adenovirus

Detection of adenoviral

A
  • antigens by ELISA
  • Nuclear antigen by PCR
144
Q

Adenovirus

Diagnosis:

cell culture detects

A

grape like cytopathic effect

145
Q

Adenovirus - diagnosis

media used for cell culture

A

Media: HEK, PMKC, Hep-2, KB, HeLa

146
Q

Adenovirus - diagnosis

isolation depending on the clinical disease, the virus may be

A
  • Throat
  • Conjunctival swabs
  • Urine
147
Q

Adenovirus - diagnosis

solation is much more difficult from

A
  • Stool
  • rectal swab (sarap)
148
Q

adenovirus

A

shakes their ass, u should too

Myco-Viro (25 decks)

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