(2) Slow Virus and Prions Flashcards
Slow or chronic infections of the CNS
Slow Virus Infections
Incubation period for Slow Virus infection
YEAAAAAARSSSS
what are the 2 mentions slow virus infections
- Subacute Sclerosing Panencephalitis (SSPE)
- Progressive Multifocal Leukoencephalopathy (PML)
Slow Virus
- Rare disease caused by Measles virus
- occurs 2-10 years after recovery from measles
Subacute Sclerosing Panencephalitis (SSPE)
Slow Virus
what happens with the CNS in Subacute Sclerosing Panencephalitis (SSPE)
Slow progressive demyelination in the CNS = ending in death :(
Slow Virus
what are the initial symptoms of Subacute Sclerosing Panencephalitis (SSPE)
- memory loss
- irritability
- seizures
- involuntary muscle movements
- and/or behavioral changes
all symptoms leading to neurological deterioration and death
Slow Virus
what are found in the neurons and glial cells with SSPE infection
Large numbers of viral nucleocapsid
Slow Virus
Caused by JC virus (a polyomavirus)
Progressive Multifocal Leukoencephalopathy (PML)
Slow Virus
John Cunningham virus, a ds-DNA, icosahedral, and
naked
JC virus (a polyomavirus)
Slow virus
- Rare
- 85% of adults in the general population have the virus
Progressive Multifocal Leukoencephalopathy (PML)
Slow virus
PML virus usually remain dormant in what sites of the body
lymph nodes, bone
marrow, or kidneys throughout our lifetime
TOF
PML can cause CNS complication that occurs in immunocompromised
individuals (e.g., AIDS patients)
True
- Small, proteinaceous particles
- no nucleic acid
Prions
Cellular prion protein
PrPC
A modified prion
PrPSC