(2) Retroviridae Flashcards
what are the seven genera of retroviridae
- Alpharetrovirus
- Betaretrovirus
- Gammaretrovirus
- Deltaretrovirus
- Epsilonretrovirus
- Spumavirus
- Lentivirus
most important genera according to doc g
Deltaretrovirus
Human T-lymphotropic viruses, bovine leukemia virus
HUMAN T-LYMPHOTROPIC VIRUSES
The causative agent of:
- adult T cell leukemia-lymphomas (ATL)
- Tropical Spastic Paraparesis (TSP)
HTLV-1
HUMAN T-LYMPHOTROPIC VIRUSES
Isolated but has not been conclusively associated with a specific disease
HTLV-2
HTLV-1 and HTLV-2 share what common ground
65% sequence homology
and display significant serologic cross-reactivity
TOF
Retroviruses are cis-regulating
TRANS-REGULATING
HTLV-1 and HTLV-2 carry what gene, which product alters the
expression of other viral genes
gene and tax
TOF
distributed endmically
F
worldwide
how many individual are infected?
10 to 20 million
Clusters of HTLV-associated disease are found in certain
geographic areas
- Southern Japan
- Melanesia
- The Caribbean
- Central and South America
- Parts of Africa
Seroepidemiology has linked infection with HTLV-1 to a syndrome called
HTLV-1- associated myelopathy (HAM) / tropical spastic paraparesis (TSP)
The primary clinical feature
development of
progressive weakness of the legs and lower body
The patient’s mental faculties remain intact.
described as being of the same magnitude and importance in the tropics as is multiple sclerosis in Western countries
HAM/TSP
Transmission, enumerate
- Involve cell-associated virus
- Mother-to-child offers a 15-25% transmission
- Blood transfusion
- Sharing of blood-contaminated needles (drug users)
- Sexual intercourse
