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Myco-Viro > (3) Superficial, Cutaneous, & Subcutaneous Fungi > Flashcards

(3) Superficial, Cutaneous, & Subcutaneous Fungi Flashcards

1
Q

Key Concepts of Superficial and Cutaneous Fungi

TOF

Superficial and cutaneous mycoses are among the most common of all non-communicable diseases

A

F

COMMUNICABLE

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2
Q

Key Concepts of Superficial and Cutaneous Fungi

Most superficial and cutaneous fungal infections are caused by species of?

A
  • Malassezia
  • Dermatophytes
  • Candida
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3
Q

Key Concepts of Superficial and Cutaneous Fungi

TOF

The growth of dermatophytes is excited by serum and body temperature, and these fungi
rarely become invasive

A

F

INHIBITED not Excited

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4
Q

Key Concepts of Superficial and Cutaneous Fungi

TOF

Geophilic and zoophilic dermatophytes usually cause acute, inflammatory lesions that respond
to topical treatment within weeks and rarely recur

A

True

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5
Q

Key Concepts of Superficial and Cutaneous Fungi

TOF

aAnthropophilic dermatophytes usually cause relatively mild, chronic lesions that may require
months or years of treatment and frequently recur.

A

F

Anthrophilic

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6
Q

this fungi has deeper site of infectivity

A

Subcutaneous fungi

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7
Q

give the characterisitc of Subcutaneous fungi

A
  • acquired through Skin Trauma or Skin prick
  • The genus and species inhabit the Soil -habitat
  • Biopsy to observe granules
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8
Q

Give the genus and spp under the subcutaneous fungi

but not really genus and spp

A
  1. Spotohrix schenckii
  2. Madura foot agents
  3. Chromoblastomycosis agent
  4. Rhinosporidium seeberi
  5. Loboa loboi
  6. Subcutaneous zygomycosis
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9
Q

Subcutaneous Fungi

this fungi invades the tissue and when seen under the microscope it has a cigar shaped bodies (asteroid body) - Yeast form

A

Spotohrix schenckii

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10
Q

Subcutaneous Fungi

It is dimorphic in form and when In mold (the form) it has a flowerette conidia

A

Spothorix schenckii

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11
Q

Subcutaneous Fungi

what form does the spothorix schenckii on the ff characteristics

  • In RT
  • Flowerette conidia or DAISY LIKE
  • Infectious form (when enters the body)
  • When in the body it can transform into a yeast form
A

Mold Form

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12
Q

what form does the spothorix schenckii on the ff characteristics

  • Cigar shaped
  • Tissue Form
A

Yeast Form

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13
Q

Subcutaneous Fungi

This is a fungi that is associated with a disease called Rose Gardener’s Disease, common in gardeners

A

Sporothrix Schenckii

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14
Q

Sporothrix Schenckii infection are described as cord like multiple subcutaneous nodules

A

Rose gardener’s disease

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15
Q

Subcutaneous Fungi

In lab diagnosis of Sporothrix Schenckii what is the growth on the culture (describe the colony)

A

white, cream, black, moist colonies

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16
Q

Subcutaneous Fungi

This organism infect the FOOT

A

Madura Foot Agents

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17
Q

Identify the Madura Foot Agent

Actinomycetes (Nocardia, Streptomyces) can cause similar infection: CAUSATIVE AGENT OF MADURA INFCETION

A

Bacterial

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18
Q

Identify the Madura Foot Agent

  • Pseudallescheria boydii (Most common cause)
  • Madurella, Leptosphaeria, etc
  • stained with PAS or H and E stain, granules can be seen
A

Fungal

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19
Q

Madura Foot Agents

Once it infects the body, the
yeast or tissue form produces
____ inside the infectivity

this is also shown when the sample is stained and for IDENTIFICATIOn

A

Granules

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20
Q

Madura Foot Agents

what is the lesion call for madara foot agent

note that fluid are secreted on these tracts

A

Granulomatous lesions on foot with multiple draining sinus tracts

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21
Q

Madura Foot Agents

what lab specimen is used for its lab diagnosis and how is it processeds

A
  1. Collect granules from sinuses, place sterile gauze overnight.
  2. Culture granules to grow etiologic agents.
  3. Tissue biopsy; H & E staining
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22
Q

Madura Foot Agents

Match the FF

  1. Black Grains
  2. White Grains
  3. Red Grains

a. Streptomyces somaliensis
b. Madurella mycetomatis
c. Streptomyces pelletierii

A
  1. b
  2. a
  3. c

backla

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23
Q

Subcutaneous Agent

  • Chromoblastomycoses
  • Dematiaceous fungi (dark pigmented under microscope)
A

Chromatoblastomycosis Agent

24
Q

Subcutaneous Agent

what are the type of sporulation of Chromoblastomycose (it is to ID genus and spp)

A
  1. Phialophora verrucosa (VASE; Flask Shape)
  2. Fonsecae pedrosoi (SHORT CHAIN sporulation)
  3. Cladosporium carrianii (LONG CHAIN sporulation)
25
Q

Subcutaneous Fungi

Chromoblastomycosis agents when infected a tissue, what can be seen when stained and under micrscope

A

Infected Tissue: BROWN SCELROTIC BODIES

26
Q

Chromoblastomycosis agents causes what lesion

A

Cauliflower like lesion

27
Q

Culture is used for lab diagnosis of chromoblastomycosis, describe the colony it produse

A
  • Dark colonies w/ jet black reverse
  • Slow growing, suede-like, olive black color
28
Q

KOH of skin scrapings/ crusts of Chromolastomycosis agent shows what characteristic

A
  • Brown planate dividing rounded sclerotic bodies
  • Also as copper pennies, brown fission bodies
29
Q

Enumerate the types of conidation/sporulation (spp ID) for Chloroblastomyces

A
  1. Phialophora
  2. Cladosporium
  3. Acrotheca
30
Q

Subcutaenoues

  • Causing RHINOSPORIDIOSIS
  • Lesion: polypoid masses in the nose and pharynx producing nasal polyps
A

RHINOSPORIDIUM SEEBER

31
Q

what is the tissue form/yeast form of the rhinosporidum seeberi

A

SPORANGIUM - sac like structure filled with endospores, not culture

can be seen under the microscope

32
Q

Subcutaneous Fungi

  • Producing a disease or infection SIMILAR TO DOLPHIN DSE
  • lesion: ** keloid-like subcutaneous nodule** usually involving the upper or lower extremities.
A

Loboa loboi

33
Q

describe the tissue form of the Loboa loboi under microscope

A

Multiple budding cells in chain

34
Q
  • classification causing Entomophthoromycosis
  • Caused by Conidiobolus coronatus-Rhinoentomophthoromycosis
  • Caused by Basidiobolus haptosporus-Subcutaneous Phycomycosis
A

Subcutaneous Zygomycosis

35
Q

It is a member of subdivision ZYGOMYCOTA

A
  • Non-septate Hyphae
  • Reproduce by zygospores (sexual)
36
Q

what is called the When you get infected, in the tissue by a Subcutaneous Zygomycosis fungi

A

Splendore-Hoeppli phenomenonon

37
Q

Subcutaneous Zygomycosis fungi

describe the Splendore-Hoeppli phenomenonon in tissue

A

Pink proteinaceous coat, around hyphae

can be seen when you stain

38
Q

Subcutaneous Zygomycosis fungi

other name of Entomophthromycosis

A

Conidiobolus

This name is more specific for the disease

39
Q

Subcutaneous Zygomycosis fungi

  • Chronic inflammatory or granulomatous disease restricted to the nasal submucosa.
  • Characterized by polyps or palpable subcutaneous masses.
A

Conidiobolus

40
Q

TOF

Subcutaneous Zygomycosis fungi is marked by swelling of the nose and perinasal tissued extending to the anal refion

A

F

extending to the periorbital region

bobo pano umabot ng anal region

41
Q

Subcutaneous Zygomycosis fungi etiologic agent

A

Conidiobolus coronatus

  • Present in soil & decaying leaves
42
Q

Subcutaneous Zygomycosis fungi

enumerATE the lab diagnosis

A
  • H & E stain of tissue biopsy
  • Culture on SDA then microscopic
43
Q

Subcutaneous Zygomycosis fungi

what is the observation under the H&E stain of tissue biopsy

A

Broad sparsely septate hyphae surrounded by eosinophilic sheath

44
Q

Subcutaneous Zygomycosis fungi

Characteristic of the CULTURE ON SDA

A

Flat, cream colored, glabrous, radially folded colony covered by fine, powdery, white surface mycelium.

45
Q

Subcutaneous Zygomycosis fungi

Describe the morphology under microscope

A

Spherical sporangiola (conidia) with hair-like appendages (villae)

46
Q

LABORATORY DIAGNOSIS OF

SUBCUTANEOUS FUNGI IN GENERAL:

specimen submitted and how it can be processed

A

Pus (specimen)
- Exudate
- Biopsy
- KOH
- Culture
- Serology,
- Histologic stain

47
Q

TREATMENT OF SUBCUTANEOUS
MYCOSES

enumerate

A
  • Antifungal agent Amphotericin B
  • Surgical removal of infected tissue, amputation (kapag Malaki na)
48
Q

KEY CONCEPTS: SUBCUTANEOUS

MYCOSES

TOF

Subcutaneous mycoses may be caused by dozens of
environmental molds associated with vegetation and soil

49
Q

KEY CONCEPTS: SUBCUTANEOUS MYCOSES

These infections are usually acquired when?

A

**minor cuts ** or scratches introduce soil or plant debris (eg, splinters, thorns) containing the pathogenic fungus

50
Q

KEY CONCEPTS: SUBCUTANEOUS MYCOSES

TOF

The ensuing infections are
frequently ACute but rarely spread to deeper tissues

51
Q

KEY CONCEPTS: SUBCUTANEOUS MYCOSES

S schenckii, the cause of sporotrichosis, is a?

A

DIMORPHIC FUNGUS

converts from hyphal growth to yeast cells within the host

52
Q

KEY CONCEPTS: SUBCUTANEOUS MYCOSES

The diagnostic feature of chromoblastomycosis is the
microscopic observation of?

A

brownish (melanized), spherical sclerotic bodies within the lesions

53
Q

KEY CONCEPTS: SUBCUTANEOUS MYCOSES

The diagnostic feature of phaeohyphomycosis is the presence of?

A

brownish (melanized), septate hyphae within the lesions

54
Q

KEY CONCEPTS: SUBCUTANEOUS MYCOSES

The hallmark of a mycetoma is ____ and the formation of ____ that contain hard granules composed of
hyphae and inflammatory tissue (eg, macrophages, fibrin)

A
  • localized swelling
  • Fistulate
55
Q

KEY CONCEPTS: SUBCUTANEOUS MYCOSES

The hallmark of a mycetoma is localized swelling and the
formation of fistulae that contain hard granules composed of?

A

hyphae and inflammatory tissue (eg, macrophages, fibrin)

56
Q

wow

A

ur done, jump

Myco-Viro (25 decks)

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