(1) Picornaviridae Flashcards
Picornaviridae have large family of viruses but what is their SIZE
small
q
Pico is a spanish term which menas?
Little bit
characteristic of Picornaviridae
- Small protien
- Positive ssRNA
- naked
- Icosahedral
viral capsid consists of?
60 sub-unit with 4 proteins
Viral capsid consists of 60 subunits with 4 proteins which are
Viral proteins 1-4
TOF
Picornaviridae are resistant to alcohol or downy?
False (downy is not a detergent)
Alcohol and Detergent
how many genera does picornaviridae have?
12 genera
from the 12 genera of the picornaviridae, what are the 2 MAJOR pathogens
Rhinoviruses and Enteroviruses
PICORNAVIRIDAE
acid labile and the common
causative agents of the common cold.
Rhinoviruses
PICORNAVIRIDAE
what journal state that drinking citrus drinks will help with common cold
HA NONE BOBO
theres no such evidence proving that it is effective
PICORNAVIRIDAE
stable at acidic pH (3.0-5.0)
and can remain infectious for 1-3 hours
Enteroviruses
enumerate the viruses of the picornaviridae
- Enterovirus
- Hepatovirus
- Kobuvirus
- Parechovirus
- Cardiovirus
- Aphthovirus
Causative agents of heart disease in rodents
Cardiovirus
foot-and-mouth disease viruses
o Commonly seen in cattle and piglets
Aphthovirus
if u see this card
kindly check the table for the characteristic of human picornaviruses
Enteroviruses can be isolated from?
enteric GIT
“entero”
PICORNAVIRIDAE
what are the serotypes of poiioviruses
PV1, PV2, PV3
Rhinoviruses can be isolated in?
upper respiratory
tract—in the nose and the throat
“rhino”
what characteristic polioviruses have against other viruses, it is connected with their immunity
Minimal heterotypic immunity
what is minimal heterotypic immunity
one serotype does not produce a significant immunity against the other serotypes
Polioviruses caause what life threatening disease?
Polio or Poliomyelitis
Incubation period of poliovirus
7 to 14 days
MOT of Poliovirus
fecal-oral route
Incubation for polivirus can be as short and long as?
as short as 3 days or as long as
33 days
Poliovirus - Pathogenesis
Fecal oral route →
travels in GI tract
Poliovirus - Pathogenesis
Travels in GI tract →
infects small intesting/oral pharynx epithelium
primary sites of replication
Poliovirus - Pathogenesis
spread to CNS by?
viremia or retrograde transport in peripheral nerves
(exact mechanism unknown
Poliovirus - Pathogenesis
infects small intesting/oral pharynx epithelium →
replicates in submucosal lymphoid tissue
Poliovirus - Pathogenesis
replicates in submucosal lymphoid tissue →
transient viremia
Poliovirus - Pathogenesis
binds to the receptors of?
anterior horn motor neurons
Poliovirus - Pathogenesis
what are the target site of the virus
anterior horn motor neurons
Poliovirus - Pathogenesis
where will it replicate, and lyse
motor neurons
anterior horn motor neurons
Poliovirus - Pathogenesis
what are the possible ways of innervating on the anterior horn motor neurons
- Distal muscles
- Proximal muscle
Poliovirus - Pathogenesis
produce a lower motor neuron disease
distal muscles
Poliovirus - Pathogenesis
what does the distal muscles infection includes
lower extremities which
is indicated by asymmetrical limbs and the
like
Poliovirus - Pathogenesis
what part may lead to respiratory
insufficiency and possible death infection
proximal muscles
Poliovirus - Pathogenesis
what does the proximal muscles infection includes
Proximal muscles mainly include the chest which affects the muscles of respiration.
`
Poliovirus - Pathogenesis
what immunoglobulin are produced
- IgG
- secretory IgA
Poliovirus - Pathogenesis
at will protect the host against future
infections
lasting immunity from the immunoglobulins
enumerate the clinical findings of the poliovirus
- Asymptomatic
- Mild disease
- Non-paralytic poliomyelitis
- paralytic poliomyelitis
- Progressive Post-poliomyelitis muscle atrophy
Poliovirus - Clinical Findings
- Most common form
- Non-specific flu-like symptoms such as sore throat, fever, malaise, nausea, headache, stomach pain
Mild Disease
Poliovirus - Clinical Findings
what percentage or approximation does patients present milder form of the disease
1 out of 4 patients
Poliovirus - Clinical Findings
- Also known as the aseptic meningitis
- Occurs in 1-5 out of 100 people with poliovirus
Non-Paralytic Poliomyelitis