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Myco-Viro > (2) Herpes, and Poxvirus > Flashcards

(2) Herpes, and Poxvirus Flashcards

1
Q

Cytomegalovirus (CMV)

Official name

A

Human Herpesvirus 5

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2
Q

Cytomegalovirus (CMV)

Most common cause of

A

iral congenital infection (Infection of the newborn babies)

can lead to severe abnormalities

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3
Q

Cytomegalovirus (CMV)

nfection is common during?

A

during childhood and adolescence

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4
Q

Cytomegalovirus (CMV)

infections are typically?

A

asymptomatic

(severe infections can occur in immunocompromised patients)

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5
Q

Cytomegalovirus (CMV)

Mode of transmission

A

transplacental, oral, sexual and by blood and tissue transplant

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6
Q

CMV: Pathogenesis

what happen when the virus is acquired from the blood, tissue or other body fluids

A

CMV cause a productive infection of the epithelial cells

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7
Q

CMV: Pathogenesis

In immunoncompromised patients, reactivating CMV diseases develops?

A

severe presentation

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8
Q

CMV: Pathogenesis

Site of latency

A

T-cells, macrophages, monocytes, and renal tubules

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9
Q

CMV: Clinical Manifestation (findings)

Enumerate the disease involve:

A
  • Congenital Infection
  • Postnatal Infection
  • pneumonitis, gastrointestinal infection and encepalopathy
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10
Q

CMV: Clinical Manifestation (findings)

Can result in death of the fetus in utero

A

Congenital Infection

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11
Q

CMV: Clinical Manifestation (findings)

for congenical infection, the Cytomegalic inclusion disease of newborns Characterized by

A

involvement Of the central nervous system and reticuloendothelial systems

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12
Q

CMV: Clinical Manifestation (findings)

clinical findigns under the congenital infection

A
  • ntrauterine growth
  • retardation
  • jaundice
  • hepatosplenomegaly
  • thrombocytopenia
  • microcephaly
  • retinitis
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13
Q

CMV: Clinical Manifestation (findings)

infections mononucleosis like illness (heterophil antibody negative)

A

Postnatal infection

main distinction from IM of the EBV

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14
Q

CMV: Clinical Manifestation (findings)

TOF

Signs and symtoms are alike with IM of the EBV

A

T - heterophil antibody negative yung main difference

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15
Q

CMV: Clinical Manifestation (findings)

pneumonitis, gastrointestinal infection and encepalopathy

A

Immunocompromised Patients

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16
Q

Lab Diagnosis: CMV

enumerate

A
  1. Isolation of Virus
  2. Direct Microscopy Examination
  3. Serology
  4. Molecular Assay
  5. Antigemia Test- Rapid test in serology
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17
Q

Lab Diagnosis: CMV (isolation)

what should be isolated from the virus?

A

Human Diploid Fibroblast (HDF) cell

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18
Q

Lab Diagnosis: CMV (isolation)

appearance of cytologic changes occurs after 2-3 weeks

A

Human Diploid Fibroblast (HDF) cel

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19
Q

Lab Diagnosis: CMV (isolation)

Cytopathic effect?

A

SWOLLEN TRANSLUCENT CELLS WITH LARGE INTRANUCLEAR INCLUSION

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20
Q

Lab Diagnosis: CMV (isolation)

For rapid method

A

DEAFF TEST (Detection of early antigen fluorescent foci)

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21
Q

Lab Diagnosis: CMV (isolation)

process of DEAFF Test

A

Specimen is inoculated into cell culture and examined after 24 hours by immunofluorescence for expressed CMV encoded early proteins (this is what looked for)

Viral proteins fluoresce

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22
Q

Lab Diagnosis: CMV (Direct microscopic)

what are the specimen for GIEMSA Stain

A

Urine or tissue

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23
Q

Lab Diagnosis: CMV (Direct microscopic)

what inclusion should be seen from PAP or Giems stain (Urine/tissue)

A

“OWL EYE” inclusion

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24
Q

Lab Diagnosis: CMV (Serology)

ANtibody tests

A

serology

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25
Q

Lab Diagnosis: CMV (Serology)

present infection and also found in patients with reactivation

A

CMV IgM

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26
Q

Lab Diagnosis: CMV (Serology)

past infection

A

CMV IgG

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27
Q

Lab Diagnosis: CMV

what molecular assay technique can be used

A

PCR - can provide quantitativeviral load in the blood, CSF, and urine

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28
Q

Lab Diagnosis: CMV

Antigemia Test- Rapid test in serology, what should be detected

A

CMV PP65

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29
Q

Lab Diagnosis: CMV (antifemia)

CMV PP65 should be detected in?

A

Detected in nuclei or peripheral blood neutrophils

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30
Q

CMV: Treatment, Prevention and Control

TOF

Screening of transplant donors and recipients for CMV antibody may prevent some transmissions of primary CMV

A

True

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31
Q

CMV: Treatment, Prevention and Control

immunocompromised patient can take what medicine?

A

ganciclovir, forscarne, and cidofovir

antiviral drugs

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32
Q

Human Herpes Virus 6 (HHV-6)

first recognized in what year?

A

1986

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33
Q

Human Herpes Virus 6 (HHV-6)

Genome of the virus resembles that of ?

A

human CMV

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34
Q

Human Herpes Virus 6 (HHV-6)

Mode Of transmission

A

Oral secretions

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35
Q

HHV-6: Pathogenesis

When the virus is present in the saliva, it causes an infection in the

A

oropharynx

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36
Q

HHV-6: Pathogenesis

The virus will grow well in the

A

CD4 T - lymphocytes

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37
Q

HHV-6: Pathogenesis

The virus will grow well in the CD4 T - lymphocytes and can also replicate in

A
  • B-cells
  • cells of glial
  • fibroblastoid
  • megakaryocyte origin
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38
Q

HHV-6: Pathogenesis

important cellular receptor

A

HUMAN CD46

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39
Q

HHV-6: Clinical Manifestation

Roseola infantum, or “sixth disease” of childhood

A

Exanthem Subitum

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40
Q

HHV-6: Clinical Manifestation

exanthem subitum are mild common childhood disaese characterizeed by?

A

high fever and skin rash

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41
Q

HHV-6: Clinical Manifestation

reactivation is common in?

A

transplant patients and during pregnancy

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42
Q

HHV-6: Clinical Manifestation

reactivation is common in transplant patients and during pregnancy and may cause

A

encephalitis, pneumonitis, or chorioretinitis

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43
Q

Lab Diagnosis: HHV-6

basis for diagnosis?

A

Clinical findings

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44
Q

Lab Diagnosis: HHV-6

TOF

Culture- practical

A

F (not practical)

Lab Diagnosis: HHV-6

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45
Q

Lab Diagnosis: HHV-6

TOF

kantology — IgM (present infection) and IgG (past infection)

A

F (serology)

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46
Q

Human Herpes Virus 7 (HHV-7)

also known as:

A

T-Lymphotropic Human Herpesvirus

47
Q

Human Herpes Virus 7 (HHV-7)

First isolated in

A

1990

48
Q

Human Herpes Virus 7 (HHV-7)

isolated from

A

acitvated T cells

49
Q

Human Herpes Virus 7 (HHV-7)

where was the activated t cells recovered?

A

peripheral blood lymphocytes of a healthy individual

50
Q

Human Herpes Virus 7 (HHV-7)

Infections commonly occur during

A

childhood along with HHV - 6

51
Q

Human Herpes Virus 7 (HHV-7)

Persistent infection is established in the

A

Salivary glands

52
Q

Kaposi Sarcoma Herpes Virus (KSHV)

Official name

A

Human Herpes Virus -8 (HHV-8)

53
Q

Kaposi Sarcoma Herpes Virus (KSHV)

Lymphotropic closely related to?

A

EBV

54
Q

Kaposi Sarcoma Herpes Virus (KSHV)

Mode of transmission

A

Contact with oral secretions

55
Q

Kaposi Sarcoma Herpes Virus (KSHV)

it can cause?

A

Kaposi sarcoma - vascular tumors of mixed cellular composition

56
Q

Kaposi Sarcoma Herpes Virus (KSHV)

Kaposi sarcoma is commonly involved in the pathogenesis of body cavity-based lymphomas occurring in whose patients

A

AIDS patients and Of multicentric Castleman disease

57
Q

Kaposi Sarcoma Herpes Virus (KSHV)

number 1 cancer of ?

A

aids patient

58
Q

Kaposi Sarcoma Herpes Virus (KSHV)

diagnosis is made through using?

A

antibodies

59
Q

Kaposi Sarcoma Herpes Virus (KSHV)

Diagnosis used to measure antibodies to KHSV:

A

Serological assays:

60
Q

Kaposi Sarcoma Herpes Virus (KSHV)

what serological assays could be use?

A
  • indirect immunofluorescence
  • Western blot
  • enzyme - linked immunosorbent assay may be used to measure
61
Q

Poxvirus

give the characteristic

A
  • dSDNNA
  • Enveloped
  • Complex
  • Linear
62
Q

Poxvirus

shape

A

BRICK-SHAPED

63
Q

Poxvirus

TOF

Largest plant virus

A

F (animal)

64
Q

Poxvirus

inclusion

A

GUARNIERI BODIES

use electron micrscopy

65
Q

Poxvirus

saan makikita lesions

A

Vesicular skin lesion in the susceptible host

66
Q

Poxvirus

Replication occurs in the

A

Cytoplasm

67
Q

Poxvirus

Pox virus the cause disease to human

A

SMALLPOX

68
Q

Smallpox

Caused by

A

VARIOLA VIRUS of the genus ORTHOPOXVIRUS

69
Q

Smallpox

what are the 2 main forms of Variola virus

A
  • Variola Major: causative agent of small pox
  • Variola Minor: causative agent of ALASTRIM (milder from of smallpox)
70
Q

Smallpox

causative agent of small pox

A

Variola major

71
Q

Smallpox

causative agent of alastrim (milder from of small pox)

A

Variola minor

72
Q

Smallpox

The name Of the disease is derived from the latin word

A

‘spotted’

73
Q

Smallpox

spotted means?

A

which to the raised bumps that appear on the face and body of an infected person

74
Q

Smallpox - History

Earliest record of smallpox infection

A

Egypt, 2000BC

75
Q

Smallpox - History

Widespread of infection in India

A

1st century BC

76
Q

Smallpox - History

Widespread of infection in Asia and Europe

A

800 AD

77
Q

Smallpox - History

Eradication of the infection as declared by WHO

A

1978

78
Q

Smallpox - History

Mode of transmission

A

Aerosol and droplets from respiratory secretions

79
Q

Smallpox - Pathogenesis and clinical manifestation

Upon inhalation of the virus due to large droplets, will enter

A

upper respiratory system

80
Q

Smallpox - Pathogenesis and clinical manifestation

Incubation

A

10-14 days (12 days average)

81
Q

Smallpox - Pathogenesis and clinical manifestation

Primary infection and multiplication happens in the

A

Lymphoid tissue

82
Q

Smallpox - Pathogenesis and clinical manifestation

then lymphoid tissue which will drain the site of entry, and later on will result to

A

“transient viremia” or temporary viremia

83
Q

Smallpox - Pathogenesis and clinical manifestation

Infection in the reticuloendothelial cell will make abot to the

A

liver, spleen, and lungs

84
Q

Smallpox - Pathogenesis and clinical manifestation

Secondary phase of multiplication will occur in the

A

reticuloendothelial cell

85
Q

Smallpox - Pathogenesis and clinical manifestation

Secondary phase of multiplication will occur in the reticuloendothelial cell that will lead to

A

secondary more intense viremia

86
Q

Smallpox - Pathogenesis and clinical manifestation

on the clinical manifestation stage what will appear

A

Rash

87
Q

Smallpox - Pathogenesis and clinical manifestation

refer sa table for manifestation

A

okay

88
Q

Lab Diagnosis: Smallpox

Specimen of choice for viral detection and isolation.

A

Skin lesions

89
Q

Lab Diagnosis: Smallpox

Direct examination of clinical material using ____ ____may be used for rapid identification of virus particles

A

electron microscopy

90
Q

Lab Diagnosis: Smallpox

for cell culture what is used as specimen and where is it cultured

A

Specimen: Vesicular fluid
Medium: chorioallontoic membrane of chick embryos

91
Q

Lab Diagnosis: Smallpox

what is the goal for cell culture

A

Differentiate smallpox from generalized vaccinia

92
Q

Lab Diagnosis: Smallpox

after 2 to 3 days, small pocks are produced sa cell culture

A

Smallpox

93
Q

Lab Diagnosis: Smallpox

large, necrotic pocks

A

Vaccinia

94
Q

Lab Diagnosis: Smallpox

Viral antigens in vesicle fluid can be detected by precipitin tests or immunofluorescent

A

Serology

95
Q

Lab Diagnosis: Smallpox

A 4-fold increase in antibody titer in convalescent serum phase is diagnostic

A

Antibody assays

96
Q

Smallpox - Treatment, Prevention and Control

Treatment of smallpox infection is

A

mainly supportive

97
Q

Smallpox - Treatment, Prevention and Control

TOF

immunization

A

T

98
Q

Smallpox - Treatment, Prevention and Control

Earliest attempt is of immunization

A

thru variolation

99
Q

Smallpox - Treatment, Prevention and Control

TOF

1796 - Edward Jenner introduced vaccination with cowpox virus

A

T (go back to the history with lec 1 ha)

100
Q

Smallpox - Treatment, Prevention and Control

vaccination’ comes from the latin word

A

cow “vacca”

101
Q

Smallpox - Treatment, Prevention and Control

The vaccine for smallpox infection comes from the

A

Vaccinia virus

102
Q

Smallpox - Treatment, Prevention and Control

Vaccinia virus which is prepared from

A

vesicular lesions (“lymph”)

103
Q

Smallpox - Treatment, Prevention and Control

vesicular lesions (“lymph”) produced in the skin Of

A

calves or can also be grown in chick embryos

104
Q

Does not cause smallpox infection but is associated with tenderness and fever

A

Vaccinia Virus

105
Q

Source of vaccine for smallpox

A

Vaccinia Virus

106
Q

Causes zoonotic infection from sheep

A

Parapoxviruses: ORF VIRUS

107
Q

Parapoxviruses: ORF VIRUS

TOF

Causes a purulent-appearing papule locally and generally systemic symptoms.

A

F (no systemic symptoms)

108
Q

nfected areas includes the

Infected areas includes the

A
  • finger
  • hand
  • arm
  • face
109
Q

Common, benign viral infection of the skin and mucous membranes

A

Molluscipox: MOLLUSCUM CONTAGIOSUM

110
Q

Molluscipox: MOLLUSCUM CONTAGIOSUM

ommonly affecting children of ages

A

1 to 10

111
Q

Molluscipox: MOLLUSCUM CONTAGIOSUM

Spread of infection happens due to a

A

direct skin-to-skin contact with the infected individual

112
Q

Molluscipox: MOLLUSCUM CONTAGIOSUM

Lesions in the affected skin presents as

A

umbilicated papul

113
Q

if u see this card

A

check niyo mga pictures okay? okay

now twerk

Myco-Viro (5 decks)

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