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Myco-Viro > (2) Reoviridae > Flashcards

(2) Reoviridae Flashcards

1
Q

Meaning of REO in REOVIRIDAE

A

Respiratory Enteric Orphan (REO) Viruses

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2
Q

REOVIRUSES can be isolated from?

A

respiratory tract or the enteric tract

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3
Q

why is it termed as Respiratory Enteric ORPHAN viruses

A

Termed as “orphan” since it is not associated with a
specific disease

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4
Q

important genera udnder REOVIRIDAE

A
  • Rotavirus
  • Coltivirus
  • Orbivirus
  • Orthoreoviruses
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5
Q

General Characterisrtic of REOVIRIDAE

A
  • Icosahedral
  • 60-80 nm
  • Double capsid shell (EXCEPT the rotavirus which has a triple-layered shell)
  • Segmented
  • double-stranded RNA
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6
Q

where does the REOVIRIDAE replicate?

A

Cytoplasmic replication

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7
Q

REOVIRIDAE are extremely stable in what sense?

A
  • Heat Resistant
  • Infectioous at a wide range of pH: 3.0 - 9.0
  • Resistant to lipid solvent
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8
Q

what lipid solvents are the REOVIRIDAE resistant with?

A

ether and
chloroform

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9
Q

REOVIRIDAE are inactivated by?

A
  • 95% ethanol
  • phenol
  • chlorine
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10
Q

Reoviridae - Replication

The virus will attach to the cell surface through the cell
surface receptors through the ?

A

viral hemagglutinin (σ1
protein)

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11
Q

Reoviridae - Replication

a minor component of the outer capsid of the virus

A

viral hemagglutinin (σ1
protein)

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12
Q

Reoviridae - Replication

after attachment what is the next process

A

penetration and uncoating of the first layer

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13
Q

Reoviridae - Replication

penetration and uncoating of the first layer →

A

core will be released and morphogenesis will occur

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14
Q

Reoviridae - Replication

what will occur along with the releasing of core and morphogenesis

A

translation and transcription

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15
Q

Reoviridae - Replication

The mature virion will be released secondary to?

A

Cell lysis

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16
Q

if u see this card

A

check the viral replication process

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17
Q

Major cause of diarrheal illness in human and the single most important cause of gastroenteritis in children

A

Rotavirus

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18
Q

what disease are included in the ROTAVIRUS

A
  • Human infantile diarrhea
  • Nebraska calf diarrhea
  • epizootic diarrhea of infant mice
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19
Q

Rotavirus - TOF

Classified into 7 species from A-H based on the antigenic epitomes in the internal structural protein of the virus

A

F

7 nga lang diba, A-G

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20
Q

Rotavirius

Most frequent pathogen

A

A serotype

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21
Q

Rotavirius

implicated in large outbreaks of severe
gastroenteritis.

A

B serotype

22
Q

Rotavirius

predominant
serotype strains.

A

G1 to G4 and G9

23
Q

Rotavirus MOT

A

fecal-oral-route

24
Q

Rotavirus - MOT

the virus will infect the?

A

villi of the small intestine

25
Q

Rotavirus - MOT

will infect the villi of the small intestine →

A

replicate in the cytoplasm

26
Q

Rotavirus - MOT

replicate in the cytoplasm →

A

cell lysis

27
Q

Rotavirus - MOT

what will happen when cell lysis happen?

A

cause impaired absorption of carbohydrate and other nutrients

28
Q

Rotavirus - MOT

When there is an impaired absorption of carbohydrate and other nutrients, it will lead to?

A

vomiting and by watery diarrhea of
hypersecretory diarrhea with mucoid stool

not invasive, stool should not have blood

29
Q

Rotavirus incubation period lasts between?

A

1-3 days, and is vaccine preventable

30
Q

Clinical
Manifestation of Rotavirus

A
  • Watery diarrhea, fever, abdominal pain, vomiting leading to dehydration
  • TN: inflammation → (-) bloody stoot
31
Q

Immunity of rotavirus

A
  • Rotavirus antibody is maintained in adults
  • Subclinical reinfection
32
Q

Treatment of rotavirus

A

Supportive treatment targets dehydration

33
Q

Prevention (vaccine) for rotavirus

A
  • RotaTeq
  • Rotarix
34
Q

Diagnosis for rotavirus

A
  • Stool
  • ELISA
  • PCR
35
Q

Rotavirus

Watery diarrhea is due to the lysis of

A

enterocytes

36
Q

Rotavirus

water diarrhea is secondary to?

A

rotavirus encoded protein NSP4 (viral enterotoxin which induces secretion)

37
Q

Rotavirus

Supportive treatment targets dehydration which mainly consists of

A

fluid management

38
Q

Rotavirus

Gatorade should not be given in cases of dehydration due to diarrhea since the drink contains lots of ?

A

carbohydrates which will result to more diarrhea due to the impaired absorption mechanism of the enteric
tract

39
Q

Rotavirus - vaccine

an oral live attenuated pentavalent human bovine reassortant rotavirus

A

RotaTeq

40
Q

Rotavirus - vaccine

an oral live attenuated monovalent human
reassortant rotavirus vaccine

A

Rotarix

41
Q

dosage for RotaTeq and Rotarix

A
  • three (3) doses at ages 2, 4, and 6 months
  • two (2) doses at ages 2 and 4 months
42
Q
  • Natural hosts are vertebrates
  • Tropism in the epitheliums
A

ORTHOREOVIRUS

43
Q

orthoreovirus tropism can be seen in what epithelium and other sites

A
  • intestinal epithelium
  • bile duct epithelium
  • lung epithelium
  • leukocytes
  • CNS endothelial cells
44
Q

Orthoreovirus MOT

A
  • Fecal-oral route
  • respiratory inhalation of aerosol droplets
45
Q

Diseases associated with orthorevirus includes

A
  • mild upper respiratory tract disease
  • gastroenteritis
  • biliary atresia
46
Q

Orthoreovirus display what properties

A

oncolytic properties

47
Q

how many cases are there with orthoreoviruses

A

Unti pa lang

48
Q
  • Commonly infects insects
  • Transmission is through insects passing the virus to vertebrates
  • Manifests as a mild fever
A

Orbivirus

49
Q
  • Endemic to Rocky Mountains where hikers or campers are often infected following a tick bite
  • Clinical manifestations include fever, myalgia, and ocular pain.
A

Coltivurus

50
Q
A
51
Q

Enumerate ALL VIRUS that was stated in the lesson under Picronaviridae

A
  • POLIOVIRUSES (PV)
  • COXSACKIEVIRUS (CV)
  • ECHOVIRUSES
  • RHINOVIRUSES
52
Q

Enumerate ALL VIRUS that was stated in the lesson under Reoviridae

A
  • ROTAVIRUS
  • ORTHOREOVIRUS
  • ORBIVIRUS
  • COLTIVURUS

Myco-Viro (25 decks)

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