Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Myco-Viro > (2) Hepatitis Virus (HCV, HDV, HEV, & HGV) > Flashcards

(2) Hepatitis Virus (HCV, HDV, HEV, & HGV) Flashcards

1
Q

Identify the virus

  • Major public health problem
  • > 4m infected in us
  • > 170m people die worldwide
  • 12000 patients die annually (us)
A

HEPATITIS C VIRUS (HCV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q
  • Leading cause of chronic hepatitis, cirrhosis, and liver cancer.
  • Primary indication for liver transplantation in Western countries
A

Hepatitis C Virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hepa C virus are known causative agent of previously known?

A

Non-A and Non-B Hepatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hepa C Incidence rate after a single unit blood transfucsion

A

2-4%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Hepa C Virus

Identify the Family, and genus

also give the characteristive of the virus

A

Family: Flaviviridae
Genus: Hepatitis C Virus

Characteristic: Enveloped, ssRNA virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How many genotyoes are there in HEPA C?

A

6 (designated as 1-6)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is the characteristic of HEPA C Virus why is it allowed to esxape immune response and persist in the host

A

HIGH MUTATION RATE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Also known as the post-transfusion hepatitis or the non- A and non-B (NANB) hepatitis.

A

Hepatitis C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

main agent of the Hepatitis C ?

A

Hepatitis C virus malamang

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MOT of Hepa C

A
  • Parenteral (Blood Transfusion)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what stages for Hepa c may lead to liver cirrhosis and cancer

A

Acute and Chronic Stage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Treatment for Hepa C

A

Interferons and Ribavirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

HCV Risk factors

A
  • Blood transfusion before 1992
    o Testing has reduced risk to about 0.001 to 0.01% per
    unit of blood transfused.
  • Organ transplantation before 1992.
  • Occupational exposures to contaminated blood.
  • Chronic hemodialysis.
  • Possibly intranasal cocaine use, body piercing, and tattooing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Enumerate the test for HCV

A
  1. Surrogate tests
  2. Serological Test
  3. Radioummunoblot Assay
  4. RT-PCR
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

identify what test for HCV

  • An old test for HCV infection which tests if an individual has both high ALT and a (-) ANTI-HBc indicating non-reactivity to ANTI HBcAg1.
  • Non-specific
A

Surrogate Tests

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

identify what test for HCV

ELISA and RIA fir ANTI-HCV

A

Serological test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

identify what test for HCV

Specific test fo ANTI-HCV

A

Radioimmunoblot Assay (RIBA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

identify what test for HCV

In cases of persistent HCV Infection

A

RT-PCR (for HCV RNA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Interpretation Pattern of HCV markers

ANTI-HCV: -
RIBA: -
HVC RNA: +

A

Acute HCV infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Interpretation Pattern of HCV markers

ANTI-HCV: +
RIBA: +
HVC RNA: +

A

Active HCV Infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Interpretation Pattern of HCV markers

ANTI-HCV: +
RIBA: -
HVC RNA: -

A

Possible HCV Clearance & False positive HCV Test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Interpretation Pattern of HCV markers

ANTI-HCV: +
RIBA: Indeterminate
HVC RNA: -

A

Requires Further Analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

HCV markers

TOF

Serological and BIRA are correleted. Therefore, if serolofical test +, BIRA should also test +

A

F (RIBA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Identify the virus

  • Single-stranded
  • Circular RNA
  • Surrounded by envelope from HBV and containse HBsAg
A

Hepatitis D Virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Initially called delta agent, now hepatitis delta antigen

A

Hepatitis D Virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

what is the Family of HDV

A

Deltavirus

first described in italy, 1977

28
Q

what other hepa virus are associated with HDV???

A

Associated exclusively with HBV infections, either as a co-infection or as a superinfection.

28
Q
A
29
Q

TOF

HDV replication are complete RNA viruse and can cause infection by itself

A

FALSE

Replication are defective bcos it is incomplete RNA, unable to cause infection by itselg

30
Q

TOF

HDV are dependent on HBV for expression and Pathogenicity

A

T

31
Q

TOF

Hepa B can cause Hepa D, but not other way around?

A

True

32
Q

HBV + Delta Virus =??/

A

HDV

(this is the only way you can acquire Hepatitis D virus)

NEED NG HBV! kahit may delta pero wlang HBV womp womp will not be a HDV virus

33
Q

what is the replication mechanism of HDV??

A

Reverse Transcription (Force the host’s RNA polymerase to transcribe the HDV RNA genome)

34
Q

where HDV can be commonly seen?

A

Intravenous drug users and Hemophiliacs

35
Q

Prevention for HDV

A
  • No vaccine is available.
  • The only means of preventing hepatitis D infection is to
    prevent HBV infection.
36
Q

MOT of HDV

A

Parenteral and Sexual

37
Q

TOF

HDV signs and symptoms are similar with HAV

A

F (HBV)

38
Q

Markers to know if HDV is coinfected or superinfected with HBV

A

Coinfection: + for both ANTI-HDV and IgM ANTI-HBc

Superinfection= + ANTI-HDV and IgG ANTI-HBc

39
Q

Lab diagnosis for HDV

A
  • Indirect ELISA
    o ANTI-HDV
    o ANTI-HBc
  • PCR
  • Clinical findings which are similar with HBV infection.
40
Q

identify what Virus

Sporadic and epidemic hepatitis in developing countries such as India, Pakistan, Africa, and Mexico

A

Hepatitis E Virus

41
Q

Identify what Virus

Clinically resembles HAV infections

A

Hepatitis E Virus

42
Q

MOT for HEV

A

Fecal-Oral Route

43
Q

Since HEV is like HAV, what infection cannot be seen

A

No chronic infection

44
Q

TOF

HEV are associated with hepatocellular carcinoma

A

F (it should not be assoc)

45
Q

Give the Family and genus, and characeterisic of HEV

A

Family: Hepeviridae
Genus: Hepevirus

Characteristic: Nonenveloped, ssRNA

46
Q

Incubation Period of HEV

A

3-8 weeks

47
Q

what is the course of infection of HEV

A

Acute, Self-limiting Hepatitis - last 1 to 4 weeks

48
Q

what kind of hepatits are associated with HEV

A

Fulminant Hepatitis

49
Q

HEV

rapidly progressing disease and a high mortality rate; occurring more commonly in pregnant women.

A

Fulminant Hepatitis

50
Q

Identify what HEPATITIS

  • Also known as water-borne hepatitis since the virus is present in contaminated waters.
  • Main agent is the hepatitis E virus.
  • It causes high mortality rate in pregnant women.
A

Hepatitis E

51
Q

TOF

Hepatitis E have immunity mechanism

A

F (does not have)

52
Q

Enumerate the Lab diagnosis for HEV

A
  • Electron Microscopy (stool as specimen)
  • Indirect ELISA
    o ANTI-HEV IgM indicating an acute infection
    o ANTI-HEV IgG indicating a past infection
  • RT-PCR
  • Clinical Findings
53
Q

Identify what Virus

An enveloped, single-stranded RNA virus in the Flaviviridae family.

A

Hepatitis G Virus

54
Q

MOT of HGV

A
  • Bloodborne Route
  • Perinatal Route
  • SEXXX
55
Q

Detection method for HGV

A
  • RT-PCR
  • Serology
56
Q

what is the characteristic of HEPA G VIRUS that is uncertain in what concept

A

HGV consiste of group of viruses with UNCERTAIN ASSOCIATION with hepatitis

Discovered during the 1990s

57
Q

what is the other term of HGV

A
  • GB Virus Type C or GBV-C
  • Torquetenovirus (TTV also known as transfusion-transmitted virus)
58
Q

what are the disease associated with HGV accdin to lecture

A
  • Hepatitis G
  • TTV
59
Q

Identify what HEPATITIS

  • Also known as the blood-borne hepatitis, G-B, transfusion transmitted virus (TTV)
  • Main agent is the hepatitis G virus (HGV)
A

Hepatitis G

60
Q

what are the test for HEPATITIS G

A
  • Qualitative PCR assay for HGV RNA
  • No serological test available
61
Q

A single-stranded non-enveloped DNA virus belonging to the genus Annellovirus.

A

TTV

62
Q

what Genus does the TTV belongs to?

A

Annellovirus

63
Q

MOT of TTV

A
  • Parenteal
  • Fecal-oral
  • Respiratory Routes
64
Q

Detection method of TTV

A

PCR (mainly for researches)

65
Q

ENUMERATE the TOTAL HEPATITIS PROFILE

A
  • Anti - HAV IgM
  • Anti - HAV IgG
  • HBs Ag
  • HBe Ag
  • Anti-HBc IgM
  • Total Anti HBc
  • Anti - Hbs
  • Anti - HCV
  • Anti - HDB
  • Anti - GEV IgM
  • Anti - HEV IgG
65
Q

what is the

A

eme your done congrats

Just study the viral hepa table for better remembrance of the shingalings

Myco-Viro (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions