Ondansetron

Question 1

Trade name

Answer 1

Zofran

Question 2

Class

Answer 2

Anti-emetic

Question 3

Mechanism of Action

Answer 3

Prevents nausea, vomiting by blocking serotonin peripherally, centrally, and in the small intestine

Question 4

Indications

Answer 4

Administered in an effort to reduce the nausea or vomiting complication associated with certain existing medical illness, injuries, or medication side effects (first drug of choice)

Question 5

Contraindications/ Precautions

Answer 5

Known hypersensitivity to the medication; Hepatic disease

Question 6

Adverse effects

Answer 6

Bronchospasm(rare). chest pain, tachycardia, hypotension, pain at injection site, extrapyramidal symptoms, seizures.

Question 7

Routs of admint

Answer 7

SL,IM, IN, or IV/IO

Question 8

Onset of action

Answer 8

Rapid onset peak of 15-30 min and duration of 4-8hrs. Onset of IM is rapid with peak of 40min and duration is unknown

Question 9

Adult dose

Answer 9

4-8mg, slow IVP, SL,IN,or IM if no IV

Question 10

Pediatric dose

Answer 10

0.1mg/kg slow IVP, SL IN if no IV

Question 11

Special considerations

Answer 11

Give undiluted when administering IM or IV/IO
Administer IV/IO slowly over at lease 30 seconds (preferably over 2-5min)
Observe for prolonged QT intervals

Question 12

Protocols used

Answer 12

A-17: Diabetic emergencies
B-3 Pediatric resuscitation
B-14; Pediatric diabetic emergencies
E-18: intranasal medication device
E-24: WMD