Noloxone

Question 1

Trade name

Answer 1

Narcan

Question 2

Class

Answer 2

Narcotic (opioid) antagonist

Question 3

Mechanism of Action

Answer 3

Competitive inhibition at narcotic receptor sites. Reverses respiratory depression secondary to narcotices, Completely inhibits the effect of Morphine.

Question 4

Indications

Answer 4

ALOC patients with suspected/known opioid overdoses presenting with hypoventilation.respiratory arrest

Question 5

Contraindications/Precautions

Answer 5

Hypersensitivity; use with caution in narcotic-dependent patients

Question 6

Adverse effects

Answer 6

Withdrawal symptoms, especially in neonates (nausea, committing, diaphoreses, increased heart rate, falling blood pressure, tremors). Be prepared for combative patient after admin

Question 7

Incompatabilites/ Drug interaction

Answer 7

Should not be mixed with other drugs

Question 8

Routes of admin

Answer 8

Slow IV/IO push, IN, IM

Question 9

Onset of Action

Answer 9

Onset in 2min, peak variable; duration 45min

Question 10

Adult dose

Answer 10

0.01mg/kg, slow IVP/IN to total of 10mg

Question 11

Pediatric dose

Answer 11

0.01 mg/kg IVP, if ineffective five 0.1 mg/kg IVP (if IV access is unobtainable, may administer Narcan IN)

Question 12

Special considerations

Answer 12

Opioid drugs include: heroin, deluded, morphine, meperidine, codeine, methadone, lomotil, darvon, darvocet, talwin , and others. Large amounts of the drug may be needed for Darvon, darvocet, and methadone
Be prepared for Combative patients after admin

Question 13

Protocols used

Answer 13

A-3: Altered Mental Status
A-22: Overdose
E-18: MAD device
E-19: Sedation/ Pain