Morphine Sulfate Flashcards

1
Q

Trade Name

A

None

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2
Q

Class

A

Opioid analgesic (Schedule II narcotic)

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3
Q

Mechanism of Action

A

Alleviates pain by acting on the pain receptors in the brain; elevates pain threshold; depresses brainstem respiratory centers; decreases responsiveness to changes in PaCO2; increases venous capacitance (venous pooling) and decreases venous return, vasodialates arterioles, reducing preload and after load; depresses ventral nervous system, blocking sympathetic response to decrease anxiety, fear, and histamine release

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4
Q

Indications

A

Analgesia for moderate to severe pain

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5
Q

Contraindications

A

Respiratory depression, hypotension, CHF/pulmonary edema, head injury, undiagnosed abdominal pain

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6
Q

Adverse effects

A

Histamine release may cause local urticarial and hypotension, nausea, vomiting, respiratory depression, bonchospasms and bradycardia

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7
Q

Incompatibilities/ drug interactions

A

Other CNS drugs can potentiate its effect. It can be reversed by Narcan

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8
Q

Routes of admin

A

IV/IM

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9
Q

Onset of action

A

Onset in seconds, peak effect of 20 min, duration of 2-4hrs

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10
Q

Adult dose

A

2-10mg slow IVP

May repeat ever 5-15 minutes up to pain scale 2-3

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11
Q

Pediatric

A

0.05-0.1 mg/kg slow IVP, may repeat in 15-20 min

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12
Q

Special considerations

A

Use with caution in the geriatric population and those with COPD, asthma.
Narcan should be readily available as an antidote

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13
Q

Protocols used

A

A-3; Altered mental status
A-22: Overdose
E-18: Intranasal Medication device
E-19: Sedation/Pain

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