Cardene

Question 1

Generic name

Answer 1

Nicardipine

Question 2

Class

Answer 2

Calcium Channel Blocker

Question 3

Mechanism of Action

Answer 3

Inhibits calcium ion influx across the cell membrane

Question 4

Indications

Answer 4

Hypertension in subarachnoid bleeds, Hypertensive urgency/crisis

Question 5

Contraindications

Answer 5

Advanced aortic stenosis; caution in heart failure or significant LV dysfunction because of the negative inotropic effect; caution in beta blocker usage

Question 6

Adverse effects

Answer 6

Hypotension, headache, nausea, and vomiting, tachyarrhythmia

Question 7

Incompatibilities/Drug interactions

Answer 7

Possible with fentanyl and vecuronium in same line

Question 8

Routs of admin

Answer 8

IV drip. Do not push

Question 9

Onset of action

Answer 9

1-2 minutes; peak 2-7 minutes; duration of effects is 44 minutes

Question 10

Adult dose

Answer 10

2.5mg/hr - 15 mg/hr IV: titrate in increments of 2.5 mg/hr every 15 minutes

Question 11

Pediatric dose

Answer 11

Not approved

Question 12

Special Considerations

Answer 12

Most common side effect is rapid drop in blood pressure: avoid hypotension in possible stroke patient; Continuous monitor blood pressure, heart rate and EKG

May produce a prolonged duration of effect in renal and hepatic patients.

Question 13

Protocols Used

Answer 13

A-16 Hypertension