Aminophylline

Question 1

Trade Name

Answer 1

Theophyline

Question 2

Class

Answer 2

Bronchodilator, Methylxanthine

Question 3

Mechanism of Action

Answer 3

Increases force of contraction of diaphragmatic muscles through enhancement of calcium uptake through adenosine - mediated channels. Also supresses airway stimuli and relaxes smooth muschle

Question 4

Indications

Answer 4

Prolonged asystole from cardiac arrest or adensine administration

Question 5

Contraindications

Answer 5

Sensitivity to Aminophylline

Question 6

Adverse Effects

Answer 6

Nausea, vomiting, tremors, tachycardia, seizures.

Question 7

Incompatabilites/ Drug Interactions

Answer 7

DO NOT MIX WITH OTHER DRUGS. DO NOT ADMINISTER IF SOLUTION IS CLOUDY OR CRYSTALS PRESENT

Question 8

Routs of Administration

Answer 8

IV IO

Question 9

Onset of Action

Answer 9

Onset less than 15 min, duration 4.5 hrs

Question 10

Adult Dose

Answer 10

500mg IV over 2-3 min

Question 11

Pediatric dose

Answer 11

5mg/kg IV over 2-3 min

Question 12

Special considerations

Answer 12

Watch for hypotension with rapid administration.

Question 13

Protocols used

Answer 13

A-5 Chest pain

A-8 Asystole/PEA

A-9 Bradycardia

A-10 V-fib/V-tach

A-12 PSVT

B-6 Pediatric Asystole/PEA

B-7 Pediatric V-fib/V-tach

B-9 PSVT Pediatric PSVT