Enalaprilat

Question 1

Trade name

Answer 1

Vasotec

Question 2

Class

Answer 2

Cardiosvacular agent; Antihypertensive/ACE inhibitor

Question 3

Mechanism of Action

Answer 3

Angiotensin-converting enzyme (ACE) catalyzes the conversion of Angiotensin 1 to angiotensin II, which is a potent vasoconstrictive substance. As such, the inhibition of ACE by this drug decreases levels of angiotensin II, which leads to a drop in blood pressure from inhibited vasoconstrictive stimulation. It is also known to lower the pulmonary capillary wedge pressure (PCWP)

Question 4

Indication

Answer 4

Used in management of mild to moderate hypertension. this drug can be used in combination therapy for CHF or in acute myocardial infarction because the drugs effects deviser both preload and after load to the heart

Question 5

Contraindications/ Precautions

Answer 5

Pregnancy; history of angioedema related to previous treatment with an ACE inhibitor; pre-existing hypotension; cariogenic shock’ know hypersensitivity to ACE inhibitors

Question 6

Adverse effects

Answer 6

Hypotension or postural hypotension. The patient may also experience reflexive tachycardia with heart palpitations. Patient may display angioedema, nausea. committing, alterations in kidney function and hyperkalemia

Question 7

Routes of admin

Answer 7

IV

Question 8

Onset of Action

Answer 8

Onset within 1 hour, peak 4-6 hrs, duration at least 24hrs

Question 9

Adult dose

Answer 9

1.25 mg, ivp

Question 10

Pediatric dose

Answer 10

Not indicated

Question 11

Special considerations

Answer 11

Use cautiously with patients with renal impairment or renal artery stenosis, on diuretic therapy, or undergoing dialysis
Monitor blood pressure and cardiac rhythm closely
Serial lab values should be monitored closely so that potassium levels can be watched for hyperkalemia

Question 12

Protocols used

Answer 12

A-5 Chest pain
A-6 CHF
A-6b CPAP