Nephrology Flashcards
Nephritic
OHH
Oliguria
Hypertension
Hematuria
Azotemia
Nephrotic
PALE (EPHAL)
Proteinuria (nephrotic range)
Albumin low
Lipid high
Edema
Grossly red urine
LOWER URINARY TRACT
brown, cola, tea, burgundy colored urine
proteinuria >100 mg/dL
RBC casts
dysmorphic EBCs (acanthocytes)
GLOMERULAR
leukocytes or renal tubular casts
TUBULAR SYSTEM
Documentation of prior strep infection
ASO - throat
DNAse B antigen - skin
Serotype ff throat infection
1,2,4,12,18,25
Serotype ff THROAT infection
49,55,57,60
Patient develops nephritic syndrome how many weeks after throat infection
1-2 weeks
Patient develops nephritic syndrome how many weeks after skin infection
3-6 weeks
Poststreptococcal Glomerulonephritis
5-12 y/o
RARE before 3 y/o
LM: diffuse proliferation
IF: granular IgG, C3
EM: subepithelial humps
Laboratory findings Poststreptococcal Glomerulonephritis
INCREASED ASO titers
(+) streptozyme
decreased C3-C9; normal C1,C4
When will the abnormalities resolve
urinary protein excretion and HPN - 4-8 weeks
acute phase - 6-8 weeks
C3 level - 6-8 weeks
microscopic hematuria - 1-2 years
The only causes of renal insufficiency that cause DECREASED C3
PSGN
MPGN
Lupus Nephritis
Indications for Renal Biopsy in APSGN
acute renal failure nephrotic syndrome (-) evidence of strep infection normal complement level hematuria and proteinuria low C3 that persists > 2 mos
Bilateral sensory hearing loss
Anterior lenticonus (pathognomonic)
macular flecks, corneal erosions
Alport Syndrome (Hereditary Nephritis)
(+) hematuria 2 of the ff *macular flecks *recurrent corneal erosions *GBM thickening or thinning *sensorineural deafness
(+) hematuria, HPN
signs of renal insufficiency
history of hemoptysis and severe RDS
Goodpasture syndrome
(+) hematuria, HPN
signs of renal insufficiency
(+) SVI 3 weeks ago
purpuric rash (buttocks) pain in the joints
Henoch Schonlein Purpura (HSV)
(+) hematuria, HPN
signs of renal insufficiency
vomiting, bloody diarrhea and fever
history of eating hamburger
dehydrated hepatosplenomegaly
hemolytic uremic syndrome (HUS )
Sudden onset of gross hematuria
febrile with LRTI or GIT infection
normal C3
IgA nephropathy
Sudden onset of gross hematuria
History of strep throat or pyoderma
severely depressed C3
APSGN
asymptomatic microscopic hematuria
wears thick glasses and hearing aid
has uncles with the same condition
Alport Syndrome (Hereditary Nephritis)
IgA nephropathy
10-35 y/o
follows viral syndrome
INCREASED serum IgA
LM: focal proliferation
IF: diffuse mesangial IgA
EM: mesangial deposits
Goodpasture syndrome
15-30
pulmonary hemorrhage; IDA
(+) anti GBM antibody
LM: focal –> diffuse proliferation w/ crescents
IF: linear IgG, C3
EM: (-) deposits
Idiopathic Rapidly Progressive Glomerulonephritis
adults
(+) ANCA (in some)
LM: crescentic GN
IF: (-) immune deposits
EM: (-) deposits
3 mechanisms of proteinuria
Glomerular proteinuria – ineffective filtration
Tubular proteinuria – ineffective reabsorption
Increase plasma protein – i.e. rhabdomyolysis
Urine dipstick
3+ - 300 mg/dL
4+ - >2g/dL
Nonpathologic causes of proteinuria
Postural
Febrile (>38 C)
Exercise - resolves after 48 h
24 hr urine protein determination
NEPHROTIC RANGE > 40 mg/m2/hr
Urine protein: Creatinine ratio
NEPHROTIC RANGE >2
Causes of Transient Proteinuria
Fever Exercise Dehydration Cold Exposure CHF Seizure Stress
Idiopathic Nephrotic Syndrome
MInimal Change Disease
Focal Segmental Glomerulosclerosis
Mesangial Proliferation
Glomerular Diseases
Membranous Nephropathy
Membranoproliferative Glomerulonephritis
3+ or 4+ proteinuria
urine protein/ creatinine ratio >2
urinary protein excretion > 3.5 h/24 hr in adults and 40 mg/m2/hr in children
normal C3 and C4
Nephrotic Syndrome (Minimal Change Disease)
increased permeability of glomerular capillary wall – proteinuria and hypoalbuminemia
PODOCYTES – EFFACEMENT of foot process, decrease number of podocytes and altered slit diaphragm – LEAKY MEMBRANES
Remission attained w/n initial 4 weeks
RESPONSE
UPCR <0.2 or < +1 protein on dipstick for 3 consecutive days
REMISSION
UPCR > 2 or > 3 dipstick for 3 consecutive days
RELAPSE