Infectious Diseases Flashcards
Approximately 80% of blood cultures that will be positive are identified at
1st 24 hr from incubation
Persistence of IgM up months
Hepatitis A
West Nile Virus
T lymphocyte independent vaccines
poor immune responses in children < 2 y/o
short term immunity
absence of an enhanced or booster response on repeat exposure to the antigen
Rotavirus vaccine should NOT be initiated in infants OLDER than
15 weeks
The final dose of rotavirus vaccine must be administered no later than
8 mo of age
The MC adverse reaction to IM immunoglobulins
pain at injection site
Hepatitis A prophylaxis
IMIg
Toxoid - modified bacterial toxin that is made non toxic and is able to induce active immune response against toxins
TOXOID VACCINE
Tetanus
Diphtheria
Minimum age for the last dose of Hep B vaccine
24 weeks
Vaccines CONTRAINDICATED in patients with X-LINKED AGAMMAGLOBULINEMIA
oral polio
smallpox
live attenuated influenza
BCG
Vaccine CONTRAINDICATED in patient with CHRONIC RENAL DISEASE
live attenuated influenza
Oral rehydration is the mainstay of treatment for pediatric traveler diarrhea and the DOC is
Macrolide (Azithromycin)
Ciprofloxacin
Endogenous pyrogens
cytokines
IL 1and IL 6
TNF a
IFN B and Y
Drugs that are known to cause fever
Vancomycin
Allopurinol
Amphotericin B
Palpebral Conjunctivitis
measles coxsackie virus TB infectious mononucleosis lymphogranulomavenereum or cat scratch disease
Bulbar Conjunctivitis
Kawasaki disease
Leptospirosis
Types of Fever
INTERMITTENT FEVER
*exaggerated circadian rhythm that includes a period of normal temp on most days
SEPTIC OR HECTIC FEVER
*extremely wide fluctuations
SUSTAINED FEVER
*persistent and does not vary by > 0.5 C/day
REMITTENT FEVER
*persistent and varies by > 0.5 C/day
RELAPSING FEVER
*febrile periods that separated by intervals of normal temp
Relative Bradycardia
Typhoid Fever
Leptospirosis
Brucellosis
Drug fever
The MC serious bacterial infection in INFANT aged 1 -3 mo
Pyelonephritis
Neutropenia is defined as an absolute neutrophil count of less than
1000 cells/mm3
Caused by defects in the chain of integrin which is required for the normal process of neutrophil aggregation and attachment to endothelial surfaces
LEUKOCYTE ADHESION DEFICIENCY
neutrophilia recurrent bacterial infection (-) pus formation delayed umbilical cord separation survival usually < 10 years slow healing ulcers
Penicillins are DOC for the ff pediatric infections
Group A and B Streptococcus
Treponema pallidum
Listeria monocytogenes
N. meningitidis (meningococcemia)
Metronidazole may increase the levels pf the ff drugs
Warfarin
Phenytoin
Lithium
Toxic Shock Syndrome
fever
hypotension
erythematous rash w/ subsequent desquamation of the hands and feet
multisystem involvement – vomiting, diarrhea, myalgias, nonfocal neurologic abnormalities, conjunctival hyperemia and strawberry tongue
Major Criteria for Staphylococcal Toxic Shock Syndrome
acute fever > 38.8
hypotension
rash (erythroderma with convalescent desquamation)