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SECOND SEM 3rd YEAR > MYCO & VIROLOGY L8 (Semis- Hepatitis Viridae) > Flashcards

MYCO & VIROLOGY L8 (Semis- Hepatitis Viridae) Flashcards

1
Q

3 Possible Causes of Hepatitis

A
  1. Infectious Agents (virus, bacteria, parasite)
  2. Alcohol
  3. Drugs (Drug-induced hepatitis)
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2
Q

Primary Hepatitis (95%) includes:

A

Hepatitis A, B, C, D, E, G virus

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3
Q

Secondary Hepatitis include

A

Yellow fever virus, EBV, CMV, HSV, Rubella virus

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4
Q

Viral Hepatitis can cause:

A
  • Chronic Hepatitis which leads to Cirrhosis and to Hepatocellular Carcinoma (w/ cirrhosis)
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5
Q

Forms of Viral Hepatitis:

A

Acute
Fulminant Acute
Subclinical
Chronic

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6
Q

No signs and symptoms

A

Subclinical

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7
Q

Leads to coma bec. of the accumulation of ammonia. Also leads to liver failure

A

Fulminant Acute

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8
Q

IDENTIFY:
Family: Picornaviridae
Genus: Enterovirus/Hepatovirus

A

Hepatitis A

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9
Q

IDENTIFY:
Family: Hepadnaviridae
Genus: Orthohepadnavirus

A

Hepatitis B

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10
Q

IDENTIFY:
Family: Flaviviridae
Genus: Hepacivirus

A

Hepatitis C

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11
Q

IDENTIFY:
Family: Hepeviridae
Genus: Hepevirus

A

Hepatitis E

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12
Q

Old Family and Genus Name of Hepatitis E

A

Family: Caliciviridae
Genus: Calicivirus

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13
Q

IDENTIFY:
Family: Flaviviridae
Genus: Flavivirus

A

Hepatitis G

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13
Q

IDENTIFY:
Family: Deltaviridae
Genus: Deltavirus

A

Hepatitis D

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14
Q

NOTE: family name ends with
-viridae, while genera ends with
-virus

A
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15
Q

Its other names include Infectious Hepatitis, Enterovirus 72, and Short Incubation Hepatitis

A

Hepatitis A

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16
Q

IDENTIFY based on the incubation period:

a) 40 - 180 days
Average 60 - 90 days

b) 30 - 50 days

c) 15 - 150 days

d): 2 - 9 weeks

e) 15 - 45 days
Average of 28 days

f) Not established

A

a) Hepatitis B
b) Hepatitis C
c) Hepatitis D
d) Hepatitis E
e) Hepatitis A
f) Hepatitis G

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17
Q

IDENTIFY: based on morphology
1) Enveloped, Icosahedral, Linear, ssRNA, 45 nm

2) Naked (resistant to ether, acid, heat at 60C for 1 hour), icosahedral, linear, ssRNA, 28 nm

3) Naked, Icosahedral, Linear, ss RNA, 30 nm

4) enveloped, Icosahedral, Circular, dsDNA, 42 nm

5) Enveloped, Circular, ssRNA, 37 nm

6) ssRNA. (Size not stated)

A

1) Hepatitis C
2) Hepatitis A
3) Hepatitis E
4) Hepatitis B
5) Hepatitis D
6) Hepatitis G

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18
Q

Indicates immunity in Hep A

A

IgG anti- HAV

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19
Q

The first one to appear in Hep A

A

HAV Ag

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20
Q

IgM anti-HAV is detected by?

A

Solid Ab ELISA

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21
Q

IgG anti-HAv is detected by?

A

Competitive inhibition ELISA

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22
Q

Treatment for Hep A

A

Supportive Care

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23
Q

Prevention/ Vaccine for Hep A

A
  • Inactivated vaccine (Twinrix) 2 doses with 1 month interval
  • Treatment of water
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24
This hepatitis is subclinical, has no Chronic Disease, and is self-limiting
Hepatitis A
25
Other names of Hepatitis B (state at least two)
1. Serum Hepatitis 2. Dane Particle 3. Long Incubation Hepatitis 4. Australian Hepatitis
26
Identify based on MOT: 1) Parenteral, Sexual Intercourse 2) fecal-oral route 3) Parenteral, Perinatal, Sexual Intercourse 4) Parenteral, Sexual Intercourse, Co-infection with Hepa B virus (HBsAg needed by the virus)
1) Hepatitis C & G 2) Hepatitis A & E 3) Hepatitis B 4) Hepatitis D
27
Treatment and vaccine for Hepatitis B
Treatment: - Supportive Care - HB immunoglobulin - Interferon - Lamivudine - Liver Transplant Vaccine: Inactivated vaccine (3 doses)
28
First marker to appear during HBV
HBsAg
28
First antibody to appear in HBV
IgM anti - HBc
28
Lifelong marker of HBV infection
IgG anti - HBc
29
No serological significance; for liver biopsy.
HBcAg
29
Last to appear for immunity in HBV
Anti-HBs
30
Epidemiological Data: Blood and blood products transfusion, contact history, and inoculation history.
HB, HC, HD, HG
30
HBV window period
Anti-HBc
30
First Generation Serologic Test for Viral Hepatitis
Ouchterlony agar plate
31
Third Generation Serologic Test for Viral Hepatitis
- RIA, ELISA, Reverse Passive Hemagglutination - Reverse Passive Latex Agglutination
32
Second Generation Serologic Test for Viral Hepatitis
Counter electrophoresis (countercurrent immunoelectrophoresis)
32
This is observed with an ***increase* in liver function test (LFT)**
Chronic Persistent Hepatitis
33
This is observed with a ***decrease* in liver function test (LFT)**
Chronic Active Hepatitis
34
Prevention/ Vaccine for Hepatitis C
No vax available
35
Treatment for Hepatitis C (SIRL)
- Supportive care - Interferon - Ribuvirin - Liver Transplant
35
Indicates TB (mg/dL)
0.2-1.0 mg/dL
36
Major cause of liver cirrhosis plus alcoholic hepatitis
Hepatitis C
37
Indicates Jaunice (mg/dL)
>2mg/dL
38
Clinical Findings of Viral Hepatitis
- Fever - Anorexia - Nausea - Vomiting - Jaundice - Dark urine - Pale feces - Elevated transaminase
39
Used for diagnosis of Hepatitis C (2pts)
Anti – HCV and HCV - RNA
40
Its symptoms include jaundice, **indigestion** and **difficulty** **sleeping**, **swelling of the feet and legs**, and liver complications (e.g. liver failure or liver cancer)
Hepatitis C
40
Used for diagnosis of Hepatitis A (3pts)
1. HAV Ag 2. IgM anti - HAV 3. IgG anti - HAV
41
Defective Virus - no gene or incomplete virus
Hepatitis D
42
Prevention/Vaccine for Hepatitis E
No vax available
42
Treatment for Hepatitis E
Supportive care Self - limiting
43
Used for diagnosis of Hepatitis E (3pts)
1. HEV Ag 2. IgM Anti-HEV 3. HEV RNA
44
Detected by ELISA, Western blot and Fluorescence Antibody Blocking Assay
IgM Anti-HEV
44
Its symptoms include nausea, vomiting, pain in the right hypochondrium, intoxication, severe weakness, malaise, bleached feces
Hepatitis E
45
Detected using RT-PCR
HEV RNA
45
Treatment for Hepatitis G
Supportive care
46
Epidemiological Data: Food, water, seasonal, age
HA, HE
47
Treatment for Chronic Hepatitis
- Symptoms Therapy - Diet - Rest - Supporting Therapy - Immunomodulator
48
Treatment for Fulminant Hepatitis
General and Supporting Therapy Rest: strict bed rest, diet
49
Protection of Susceptible Population
- Active Immunity - Passive Immunity
50
Prevention of Hepatitis
- Control of source of infection - cost off route of infection | cut off guro??

SECOND SEM 3rd YEAR (39 decks)

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