Module 9 14 Penicillin Part 2 Flashcards
Question
Answer
What severe reactions can result from inadvertent injection into an artery?
Inadvertent injection into an artery can lead to severe reactions, including gangrene, tissue necrosis, and sloughing of tissue.
Can compounds coadministered with penicillin cause adverse effects?
Yes, compounds coadministered with penicillin can cause adverse effects.
What unusual effects can the procaine component of procaine penicillin G cause when given in large doses?
The procaine component can cause bizarre behavioral effects when administered in large doses.
What can rapid administration of large intravenous doses of potassium penicillin G lead to?
Rapid administration of large intravenous doses of potassium penicillin G can lead to hyperkalemia.
What are the potential consequences of hyperkalemia caused by potassium penicillin G?
Hyperkalemia can potentially result in dysrhythmias and even cardiac arrest.
What electrolyte imbalances may arise from the use of intravenous sodium penicillin G?
Intravenous sodium penicillin G use may lead to electrolyte imbalances.
In which patient population should caution be exercised when using sodium penicillin G?
Sodium penicillin G should be used with caution in patients on sodium-restricted diets.
What is the most common cause of drug allergies?
Penicillins are the most common cause of drug allergies.
What percentage of patients who receive penicillins may experience an allergic reaction?
Allergic reactions to penicillins occur in a range of 0.4% to 7% of patients who receive them.
What is the range of severity for allergic reactions to penicillins?
The severity of allergic reactions to penicillins can vary from minor rashes to life-threatening anaphylaxis.
Is there a direct relationship between the size of the penicillin dose and the intensity of the allergic response?
No, there is no direct relationship between the dose of penicillin and the intensity of the allergic response.
Is prior exposure to penicillins necessary for an allergic reaction to occur?
Yes, prior exposure to penicillins is typically required for an allergic reaction.
Can allergic responses to penicillins occur in individuals with no prior penicillin use, and why?
Yes, allergic responses can occur in individuals with no prior penicillin use because they may have been exposed to penicillins produced by fungi or penicillins present in foods of animal origin.
Should patients allergic to one penicillin be considered allergic to all other penicillins, and why?
Yes, patients allergic to one penicillin should be considered allergic to all other penicillins due to cross-sensitivity.
What percentage of patients may also display cross-sensitivity to cephalosporins?
Approximately 1% of patients may display cross-sensitivity to cephalosporins.
Is it generally advisable to use any member of the penicillin family in patients with penicillin allergies?
No, it is generally advisable to avoid using any member of the penicillin family in patients with penicillin allergies.
What determines the use of cephalosporins in individuals with penicillin allergies?
The use of cephalosporins depends on the intensity of the allergic response. If the penicillin allergy is mild, using cephalosporins is likely safe. If it’s severe, cephalosporins should be avoided.
What should individuals allergic to penicillin be encouraged to do?
Individuals allergic to penicillin should be encouraged to wear a medical identification bracelet to alert healthcare providers to their condition.
How are penicillin reactions classified, and what are the three categories?
Penicillin reactions are classified as immediate, accelerated, and delayed.
When do immediate penicillin reactions typically occur after drug administration?
Immediate penicillin reactions occur within 2 to 30 minutes after the administration of the drug.
What is the time frame for accelerated penicillin reactions?
Accelerated penicillin reactions typically occur within 1 to 72 hours after penicillin exposure.
When do delayed penicillin reactions manifest?
Delayed penicillin reactions manifest within days to weeks after penicillin use.
What type of antibodies mediate both immediate and accelerated penicillin reactions?
Both immediate and accelerated penicillin reactions are mediated by immunoglobulin E (IgE) antibodies.