Module 2 Macrocytic-Normochromic Anemias

Question 1

How are Macrocytic-Normochromic Anemias characterized?

Answer 1

• It is characterized by nusually large stem cells (megaloblasts) in the marrow. These cells mature into erythrocytes that are unusually large in size (macrocytic), thickness, and volume
  2. Normochromic - hemoglobin content is normal

Question 2

Macrocytic-Normochromic Anemias is a results of?

Answer 2

ineffective erythrocyte DNA synthesis,

Question 3

Give causes examples of Macrocytic-Normochromic Anemias

Answer 3

commonly caused by deficiencies of vitamin B12 (cobalamin) or folate (folic acid).

Question 4

Explain what happens with

Answer 4

Macrocytic-Normochromic Anemias

Answer 5

-defective erythrocytes die prematurely, which decreases their numbers in the circulation, causing anemia.

Question 6

Eryptosis

Answer 6

Premature death of damaged erythrocytes,

Question 7

This is a common mechanism of cellular loss in individuals with anemia secondary to deficiencies of iron, infections (e.g., malaria, mycoplasma), chronic diseases (e.g., diabetes, renal disease), genetic diseases (e.g., beta-thalassemia, glucose-6-phosphate dehydrogenase [G6PD] deficiency, sickle cell trait), and myelodysplastic syndrome.3

Answer 7

Eryptosis

Question 8

What causes red blood cell growth and development to continue at unequal rates.

Answer 8

• Defective DNA synthesis in megaloblastic anemias
  -DNA synthesis and cell division are blocked or delayed.

Question 9

Asynchronous development leads to what?

Answer 9

-an overproduction of hemoglobin during prolonged cellular division.
-This process creates a larger-than-normal erythrocyte with a disproportionately small nucleus.

Question 10

Give examples of macrocytic anemia

Answer 10

-Pernicous Anemia
-Folate Deficiency anemias