Minimal Change disease (+ FSGS) Flashcards
1
Q
Which layer does minimal change disease affect?
A
the podocytes (epithlium).
2
Q
How does minimal change disease usually present?
A
As nephritic syndrome
With no other abnormalities.
3
Q
What is seen in the urine?
A
Hyaline casts
Small molecular weight proteins
4
Q
what is the management?
A
Prednisolone for 4 weeks then taper for 8 weeks.
Additional: Low salt diet Albumin infusion Diuretics Antibiotic prophylaxis
5
Q
what are the side effects of the steroids in children>
A
personality changes glucose intolerance sleep disturbance behavioural growth
6
Q
how many children will respond to steroids?
A
80% will respond - 80% of these children will need more steroids.
7
Q
what disease is usually steroid resistant?
A
Focal segmental glomerulosclerosis.
8
Q
How is steroid resistant disease treated?
A
immunosuppressants:
tacrolimus
rituximab
cyclosporin
9
Q
What are the complications of minimal change disease and the use of steroids?
A
hypovolaemia thrombosis infection acute or chronic renal failure relapsing nephrotic syndrome steroid resistance.
