IgA Nephropathy Flashcards
which layer does IgA nephropathy affect?
The mesangial cells
Why is IgA important?
Most common cause of glomerulonephritis
what presentation does IgA nephropathy usually have?
Usually nephritic syndrome (haematuria, intravascular overload and hypertension).
when does IgA nephropathy often occur?
1-2 days after an URTI.
In older children and adults.
how is IgA nephropathy diagnosis confirmed?
Confirmation biopsy - will show IgA deposits on the mesangial cells.
How is IgA nephropathy treated?
Mild disease - ACE inhibitors
Moderate/severe - Immunosuppression
What is Henoch Schonlein Purpura?
IgA related vasculitis.
What is needed for a diagnosis of HSP?
PALPABLE PURPURA
And one of the following: abdominal pain renal involvement arthritis arthralgia biopsy (showing IgA deposition)
how does IgA present?
Most common childhood vasculitis.
1-3 days post trigger.
4-6 weeks.
Its self limiting.
How many people with IgA vasculitis/HSP relapse?
1-3rd
What causes IgA/HSP?
Viral URTI
streptococcus
Drugs
How is IgA vasculitis treated LONG TERM?
Hypertension and proteinuria screening.
