haemolytic uremic syndrome r Flashcards
1
Q
what is haemolytic uremic syndrome
A
blood disorder
thrombosis in small vessels
2
Q
what pathogen can cause HUS
A
e.coli 0157
3
Q
how does e.coli 0157 cause HUS
A
produces shiga toxin
4
Q
presentation of e.coli 0157 infection
A
gastroenteritis with bloody diarrhoea
5
Q
what increases risk of HUS in e.coli infection
A
use of antibiotics and anti-motility medications
6
Q
what is the classical triad seen in HUS
A
microangiopathic haemolytic anaemia
thrombocytopenia
AKI
7
Q
presentation of HUS
A
oliguria haematuria abdominal pain lethargy irritability confusion oedema hypertension bruising
8
Q
investigations in HUS
A
blood film shows fragmented RBCs Hb level <10g/dl platelet count <150x10^9 serum creatinine - raised GFR < 80ml/min proteinuria on dipstick
9
Q
management of HUS
A
medical emergency
self limiting - supportive care
maintain normal IV volume renal replacement therapy do not give antibiotics or NSAIDs dialysis if needed transfusion if needed
